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The Lanthanum loaded CuO (LCO) nanoparticles (NPs) were successfully synthesized by precipitationthermal decomposition method and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy dispersive spectra (EDS), diffuse reflectance spectra (DRS), photoluminescence (PL), X-ray photoelectron spectroscopy (XPS) and BET surface area measurements. 10 The synthesized LCO NPs was used as nanocatalyst for the synthesis of 1, 4-disubstituted-1, 2, 3-triazoles by click reaction of substituted benzyl azides and alkynes and synthesis of propargylamines via threecomponent coupling reaction of aldehydes, alkynes and amines under ultrasonication. One-pot operation, atom-economical nature, regioselectivity and good yields are the noteworthy features of this protocol. The reusability of the prepared nanocatalyst was successfully examined six times without any appreciable loss 15 in catalytic activity.

Abstract. In this study, we have evaluated the interactions of zein microspheres with different class of drugs (hydrophobic, hydrophilic, and amphiphilic) using in vitro and in silico analysis. Zein microspheres loaded with aceclofenac, metformin, and promethazine has been developed by solvent evaporation technique and analyzed for its compatibility. The physical characterization depicted the proper encapsulation of hydrophobic drug in the microspheres. The in vitro release study revealed the sustaining ability of the microspheres in the following order: hydrophobic>hydrophilic>amphiphilic. In silico analysis also confirmed the better binding affinity and greater interactions of hydrophobic drug with zein. The above results revealed that zein is more suitable for hydrophobic drugs in the development of sustained drug delivery systems using solvent evaporation technique. The study therefore envisages a scope for identifying the most suitable polymer for a sustained drug delivery system in accordance with the nature of the drug.

A mechanochemical approach for the solvent-free synthesis of oxindole-triazole pharmacophores using recyclable CuO nanoparticles has been developed.

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