These data indicate that application of cytomegalovirus-specific T cells generated by direct selection using γ-capture is both feasible and effective in a clinical environment. These simple in vitro methodologies should allow more widespread application of virus-specific T cell immunotherapies.

Graft-versus-tumor effects can be observed after high-stringency CD8-depleted DLI, although the major toxicity remains GVHD in this high-risk patient group. The safety and efficacy profile of this approach will require testing in a randomized controlled study.

The frequency response of a modified Scheibel liquid‐liquid extraction column was experimentally determined from pulse testing data obtained by Pollock. Mathematical modeling was carried out in the frequency domain. Several non‐identical, non equilibrium, perfect mixing stage models were used to describe the dynamic behavior of the column. A signal flowgraph technique was found to be suitable for determining the theoretical frequency response of the non‐identical stage models. All models proposed in this study appeared to simulate satisfactorily the behavior of both the extract and raffinate phases. The theoretical frequency and transient responses agreed very well with experimental data

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Two methods, both based on linear programming techniques, have been applied to determining the minimum time control policy for effecting a grade change in the product from a liquid‐liquid extraction column. The method was made possible by the existence of a linear dynamic model for the column derived from a previous frequency response study of the laboratory unit. Both methods predicted policies of a partial bang‐bang nature. As expected the control paths were not the same; additional control criteria such as minimum control effort or minimum number of switchings are suggested as a means of further defining a best control policy. Suitable bounds on the controlled variables were found in the study so that physically realizable control policies were formulated.