Serum concentrations of diazepam and N‐desmethyldiazepam were measured in six adult patients following administration of 10 mg diazepam in solution by the rectal, intravenous, and intramuscular routes. Maximum serum concentrations of 121‐200 ng/ml were recorded from 10 to 20 min. after the rectal instillation, whereas following intramuscular injection the levels rose slowly and irregularly, reaching a maximum (62‐186 ng/ml) in 1 to 24 hours. The bioavailability of diazepam given by rectal instillation was found to be 50±17 per cent (mean±S. D.) as compared with the intravenous administration. The possible reasons for the low bioavailability are discussed. It is concluded that administration by rectal tube provides a useful alternative to the tablets (and intramuscular injections) when a rapid onset of effect of the drug is wanted, and when intravenous administration is not applicable or practical.
Twelve histologically verified choroidal melanomas, 15 normal fellow eyes and 4 simulating lesions (vitreous haemorrhage, choroidal haemorrhage, retinal detachment and choroidal detachment) were CT-scanned before and after intravenous contrast media (maximal attenuation in the tumours were estimated from a computerized curve corresponding to a line placed from the center of the eye, through the tumour to the outside of the bulb). The melanomas showed significantly higher precontrast attenuation (54 HU) than the control eyes (17 HU) measured in symmetrical points. Enhancement was registered in all the tumours (mean = 22 HU, P less than 0.01), but not in the control eyes. Among the simulating lesions, the retinal detachment enhanced after contrast. Indications for CT-scan of intraocular processes are diagnostic doubt in opaque media and suspected extrabulbar extension. A patient with verified, disciform organised subretinal haemorrhage scanned after the primary series showed contrast enhancement comparable to the malignant melanoma series. Also 'CT-positive' tumour eyes have to be observed over a period.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.