A total of 144 urethral swab (US) and high vaginal swab (HVS) were collected from patients in four different Hospitals in Port Harcourt: Port Harcourt Teaching Hospital, Braithwaite Memorial Hospital, Port Harcourt Investigation Centre and Nigerian Agip Oil Company Staff Clinic. Fifty-three (36.8%) samples were collected from males while 91 (63.2%) samples were collected from females. Forty-two (29.2%) yielded no growth. Sixty-four (62.7%) of the positive cultures were coagulase positive Staphylococcus aureus, 31 (30.4%) were Neisseria gonorrhea. and 7 (6.9%) were group B streptococcus. Staphylococcus aureus. maintained the highest penicillin resistance with 61 (95.3%) of them showing resistance. Twentytwo (71%) of N. gonorrhea showed resistance to penicillin while 3 (42.9%) of the group B streptococcus isolated were resistant to penicillin.
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