The prevalence of penicillin resistance in organisms that cause sexually transmitted diseases in Port Harcourt, Nigeria

Ibekwe, VI; Ubochi, K.C.; Anyanwu, B.N.

doi:10.1080/09603120050127194

Cited by 14 publications

(10 citation statements)

References 4 publications

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“…Theses phytochemical have made significant contribution in maintaining human health. The significant of drugs derived from plants cannot be over emphasized with the recent trend of high percentage of resistance of microorganisms to the present day antibiotics (Ibekwe et al, 2000). Effort has been intensified by researcher towards a search for more source of antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of Phyllanthus amarus and Parquetina nigrescens on Salmonella typhi

Oluwafemi¹,

Debiri²

2010

African Journal of Biomedical Research

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Phyllanthus amarus and Paraquetina nigrescens are economic plants grown in West Africa for antimicrobial properties. Crude aqueous (hot and cold water) and ethanolic extracts of the plants were investigated for antimicrobial activity against Salmonella typhi. The organism was collected from the University College Hospital, lbadan, Nigeria and was exposed to ten standard different antibiotics and also to crude extract of P. amarus and P. nigrescens. Agar cup diffusion method was employed fro the plants extracts while disk diffusion method for the standard antibiotics. Ethanolic extracts of P. amarus had the strongest activity against Salmonella typhi with 8.0mm zone of growth inbibition followed by hot water (4.7mm) and cold water (3.8mm). This was statistically significant at P= 0.05 when compared with hot and cold water extracts. Amongst the commercial antibioticis examined, ciprofloxacin had the highest zone of growth inhibition of 9.0mm; Oflxation (6.0mm) Amoxycillin, (4.0mm) while other antibiotics had on effect on test organism. Screening carried out on P. amarus and P. nigrescens using standard methods revealed the presence of saponins, alkaloids, tannins and cardiac glycosides. P. amarus possesses significant antimicrobial activity and confirms the justification by herbalists as extract used for treatment of typhoid fever.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of Phyllanthus amarus and Parquetina nigrescens on Salmonella typhi

Oluwafemi¹,

Debiri²

2010

African Journal of Biomedical Research

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“…Phytochemicals have made a significant contribution in maintaining human health. The significance of drugs derived from plants cannot be over emphasized with the recent trend of high percentage of resistance in microorganisms to the present day antibiotics [4]. The effort has been intensified by researcher towards a search for more plant source of antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Allamanda Cathartica Linn.: Extraction and Pharmaceutical Evaluation of Various Extracts of Leaves and Flowers

Fartyal

2016

Int J Curr Pharm Sci

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Objective: Extraction and evaluation of the antifungal activity of extracts from leaves and flowers of Allamanda cathartica (Apocynaceae) Linn.Methods: Leaves and flowers of A. cathartica were collected, dried and extracted by using well-established methods for alkaloids, flavonoids, steroids and crude extracts in polar and non-polar solvents. Extracts were screened for antifungal activity using ‘Disc Diffusion Assay’ against Candida albicans (Yeast), Aspergillus flavus and Tricophyton mentagrophyte (fungi). Inhibition zone (IZ), Activity index (AI), Minimum inhibitory concentration (MIC), Minimum fungicidal concentration (MFC) and Total activity (TA) were studied. Mean and standard deviation has also been calculated.Results: C. albicans found to be the most susceptible organism while T. mentagrophyte found to be resistant. Alkaloid of leaf (IZ= 22 mm, AI= 0.65±0.02, MIC= 0.156 mg/ml, MFC= 0.078 mg/ml, TA= 278.85 ml/g) showed the best activity against C. albicans. Pet ether extract (IZ= 12 mm, AI= 0.40±0.02, MIC= 0.312 mg/ml, MFC= 0.156 mg/ml, TA= 57.24 ml/g) and water extract (IZ= 13 mm, AI= 0.43±0.02, MIC= 0.312 mg/ml, MFC= 0.156 mg/ml, TA= 49.68 ml/g) of flower also showed very good activities against C. albicans. The range of MIC and MFC found to be 1.25-0.156 mg/ml and 0.625-0.078 mg/ml, respectively.Conclusion: Results indicate the good antifungal potency of extracts against tested microorganisms. Hence, may be explored for the formation of new antifungal drugs.

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“…But with the recent trend of high percentage resistance of microorganisms to the present day antibiotics (Ibekwe et al, 2000), efforts have been intensified by researchers towards a search for more sources of antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Bacterial activity of crude extracts of Vernonia amygdalina on clinical isolates

O.¹

2013

J. Microbiol. Antimicrob.

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The antibacterial activities and preliminary phytochemical screening of ethanolic and aqeous extract of Vernonia amygdalina was performed against clinical isolates obtained from University of Ilorin Teaching Hospital (UITH) which included Escherichia coil, Staphylococcus aureus and Pseudomonas aeruginosa. Generally, the ethanol extracts showed more activities than aqueous extracts in both samples. The extracts exhibited antibacterial activity against the test organisms (0.5 to 15.50 mm). The phytochemical screening of Vernonia amydalina showed the presence of tannins, cardiac glycosides, saponins and alkaloids. The minimum inhibitory concentration (MIC) ranged between 25 and 200 mg/ml. V. amydalina exhibited a minimum bacteriocidal concentration (MBC) of 50 mg/ml for P. aeruginosa and 125 mg/ml for S. aureus while E. coil was bacteriostastic. The crude extracts exhibited strong potency against the clinical bacteria with P. aeruginosa being the most susceptible. The antibacterial efficacy of the crude extracts is therefore discussed.

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The prevalence of penicillin resistance in organisms that cause sexually transmitted diseases in Port Harcourt, Nigeria

Cited by 14 publications

References 4 publications

Antimicrobial Effect of Phyllanthus amarus and Parquetina nigrescens on Salmonella typhi

Antimicrobial Effect of Phyllanthus amarus and Parquetina nigrescens on Salmonella typhi

Allamanda Cathartica Linn.: Extraction and Pharmaceutical Evaluation of Various Extracts of Leaves and Flowers

Bacterial activity of crude extracts of Vernonia amygdalina on clinical isolates

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