By using HPLC-ESI-MS it was shown that short-term MI exercise after primary therapy in patients with colorectal cancer was associated with lower levels of urinary 8-oxo-dG, suggesting decreased oxidative DNA damage. In contrast, HI exercise tended to increase DNA damage. A prospective trial is now warranted to prove that reduced oxidative DNA damage lowers the risk of relapse of colorectal cancer in treated patients.
Variables representing activities and participation as well as immune functions may improve Crohn's disease health status measurements on the basis of better prediction of vocational rehabilitation success.
Background/Aims: The treatment criteria developed by the European Panel on the Appropriateness of Crohn’s Disease (CD) Therapy (EPACT) have not been applied to rehabilitation. Thus, we retrospectively evaluated appropriateness of treatments during CD rehabilitation using the EPACT website. Methods: We included our 1-year inpatient rehabilitation patients that had been assigned the International Classification of Disease Code for CD. The appropriateness of treatment was assessed in CD categories exhibiting frequent treatment changes. Treatment plans were compared to EPACT recommendations. Results: Charts of 337 proven CD patients (median age 42 [range 17–65] years, 250 women, median Crohn’s Disease Activity Index 140 [range –3 to 427] units) were assigned to EPACT categories. The categories ‘steroid-dependent’ and ‘steroid-refractory’ exhibited frequent treatment changes. In these 59 patients, 16 treatments (13 azathioprine, 1 methotrexate, 2 infliximab) were rated as appropriate. One certolizumab treatment was uncertain. 22 treatments with azathioprine were inappropriate (21 due to underdosing), and 93 treatments (30 mesalamine, 59 steroid, 4 budesonide) were not rated. The number of differences between treatment plans and EPACT recommendations decreased from 45 to 25 in both CD categories (p < 0.0001). Conclusions: We introduce the EPACT website as a practical advance towards an optimal therapy in rehabilitants with steroid-dependent or -refractory CD.
Our results describe an association between rehabilitation and significant changes of CD-specific pharmacotherapy in line with current treatment guidelines. This supports the concept that future studies on effects of gastroenterological rehabilitation should control for changes in pharmacotherapy.
Large peri-auricular carcinoma resection with Keystone Design Perforator Island Flap (KDPIF) PurposeDue to the surrounding anatomy, peri-auricular tumours can be difficult surgical resections and reconstructions. Acceptable resection margins may be difficult to obtain while trying to retain vital structures. The aim of this study was to analyse extent of surgery, pathological findings and adjuvant therapy, and how they impact on outcome and survival.
MethodologyPatients with squamous cell, basal cell, melanoma and other of the peri-auricular area were reviewed that underwent large surgical resection and reconstruction with KDPIF. Outcomes were defined as mortality, recurrence and flap failure. Patients were followed for a minimum of 2 years.
ResultsThis series contained 100 patients, 69% were squamous cell carcinoma. Median age was 76 years. All underwent radical surgical resection involving either parotidectomy/other procedure with/without bone removal, and KDPIF reconstruction. 31% had positive margins, 26% had a neck dissection and 60% had post-op radiotherapy and/or chemotherapy. Mortality from disease at 2 years was 9%.
ConclusionOur results suggest that a positive pathological margin is not an independent predictor for poor disease control as suggested by O'Brien et al, and that despite advanced age and disease, this population achieved low recurrence and high survival rates.O'Brien CJ et al. ignificance of clinical stage, extent of surgery, and pathological findings in metastatic cutaneous squamous carcinoma of the parotid
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.