Nonylphenol (NP) and octylphenol (OP) are priority environmental contaminants that have a potential role as endocrine disruptors. They can be biomagnified in the food chain and pose an estrogenic health risk to human health. A 28-day oral toxicity study was performed to observe the impact of single and combined exposure to NP and OP on 5-HT transporter (SERT) as well as 5-HT receptor. Results showed that the 5-HT levels in rat plasma increased with exposure to middle-dose and high-dose NP, to high-dose OP, and to low, middle, and high doses of combined NP and OP (P < 0.05), while the 5-HT levels in rat platelets increased when exposed to NP/OP or combined NP and OP of middle or high dose (P < 0.05). The expression levels of SERT in rat platelets decreased when exposed to high-dose NP/OP or high dose of combined NP and OP (P < 0.05). Meanwhile, the expression levels of 5-HT in rat platelets decreased when exposed to high-dose NP/OP as well as combined NP and OP (P < 0.05). These findings suggested that exposure to NP and OP could influence the metabolic network of 5-hydroxytryptamine via transportation and receptor binding pathways.
For validation and demonstration of high accuracy ranging and positioning algorithms and systems, a wideband radio signal generation and acquisition testbed, tightly synchronized in time and frequency, is needed. The development of such a testbed requires solutions to several challenges. Tight time and frequency synchronization, derived from a centrally distributed time-frequency reference signal, needs to be maintained in the hardware of the transmitter and receiver nodes, and wideband signal acquisition requires sustainable data throughput between the receiver and host PC as well as data storage at GB level. This article presents a testbed for wideband radio signal acquisition, for validation and demonstration of high accuracy ranging and positioning. It consists of multiple Ettus X310 universal software radio peripherals (USRPs) and supports high accuracy (<100 ps) time-deterministic, sustainable signal transmission and acquisition, with a bandwidth up to 320 MHz (in dual channel mode) and frequencies up to 6 GHz. Generation and processing of wideband arbitrary signal waveforms is done offline. To realize these features, radio frequency on chip (RFNoC) compatible HDL units were developed for integration in the X310 SDR platform. Wideband transmission and signal acquisition at a lower duty cycle is applied to reduce the data offloading throughput to the host's personal computer (PC). Benchmarking of the platform was performed to demonstrate sustainable long duration dual channel acquisition. Indoor range measurements with the synchronous operation of the testbed show a decimeter-level accuracy.
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