Increased Expression of Id-2 in Patagialis Muscles of Coturnix Quail Following Wing Unloading and Reloading.

Cross Talk opposing view: Myonuclei do not undergo apoptosis during skeletal muscle atrophy

“…Supporting this conclusion is the observation that interventions that trigger atrophy are frequently associated with enhanced expression of apoptosis markers within the tissue, including caspase activation, genomic DNA degradation (measured via TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining or DNA ladders on agarose gels), poly (ADP-ribose) polymerase cleavage or mitochondrial endonuclease G (EndoG) release (Alway et al, 2003;Barnes et al, 2015;Dupont-Versteegden et al, 2006;Guo et al, 2012;Kletzien et al, 2017;McClung et al, 2007;Smith et al, 2000). On its face, these data appear to support the myonuclear domain hypothesis.…”