An evaluation was made on cerebrospinal fluid pressure, rectal temperature, leucoyte, blood sugar, cerebrospinal fluid and serum transaminase which occurred in the brain hemorrhage of animals, purposely prepared for clinical experiment.Matured dogs, weighting approximately 10 kg were utilized, and the Tokyo Uniuersity Brain Laboratory Type Animal Stabilizer was adopted for this experiment, and self made arterial blood was injected at the rate of 1 cc per kilogram of the dogs weight into the intraventricular and the internal capsular.The cerebrospinal fluid pressure rose 10 to 12 fold, simultaneous to the injection of the arterial blood, but the drop of the pressure continued for 2 hours thereafter, and began rising again 3 hours later. Approximately the same symptom was noticed in the blood pressure. The rectal temperature began rising rapidly after the 3rd hour, and the same action was seen in the leucocyte. The increase in the amount of blood sugar continued until the 4th hour, and in most cases a great amount of blood sugar was noticed after the 4th hour.In regard to serum transaminase, GOT indicated a significant rise after the 12th hour. The mortality in the intraventricular bleeding group showed 11.7%' during the 3rd through the 12th hour period, and 58.8% during the 12th through the 48th hour period, and the rates in the internal capsular bleeding group were 7.7% and 53.8%/,, respectively.The above mentioned facts indicate that in regard to experimentally prepared severe brain hemorrhage, the first 3 hours, after the bleeding operation being performed, is considered to be the confused period, in regard to the stress or the bleeding. During this period the fluid pressure rise rapidly and then drops, and the amount of blood sugar greatly increases, and significant changes are recognized in the blood pressure, in the rectal temperature and in the leucocyte. During the period between the 3rd through the 12th hour, a conspicuous rise in the rectal temperature and a great increase in the amount of lecucocyte are noticed, and also during this period the cerebrospinal fluid pressure begins to rise again. This period is considered to be the reaction period which the bios reaction shows a set tendency. Further, during the 12th through the 48th hour period, cerebrospinal fluid GOT indicates a significant rise; and in both groups, the intraventricular and -57-