110. Studies on Ventriculography

Abstract

A new method of positive contrast ventriculography which used emulsified Pantopaque was reported by Portera-Sanchez et al. (1964) and Kitamura et al. (1967).They produced emulsion of Pantopaque with cerebrospinal fluid by manual shaking. Ultrasonic homogenizer was used in order to produce more dense and stable emulsion in our experimental studies. The following results were obtained:1) The best condition of ultrasonic application was 180-220 W power, 25 Kc frequency, 5 min. application.2) The manipulation of producing Myodil emulsion is very simple as follows: 10-20 ml of spinal fluid are removed from the ventricular system into a glass cap containing 1-3 ml of Myodil, and it is dealed with ultrasonic homogenizer 5 min.3) A quality of emulsified Myodil is milky fluid of oil in water type emulsion, and its specific gravity was 1.010, viscosity was 1.026, pH was 6.33, Jod contain was 2.7%.4) It was obtained fine contrast by emulsified Myodil on the X ray examination using model ventricle. At present, we believe that emulsified Myodil is enough to use clinical ventriculography as a contrast medium.111.

Pharmacological Studies on 8-[(1, 4-Benzodioxan-2-Yl) Methyl]-3-Oxo-1-Thia-4, 8-Diazaspiro-[4, 5]-Decane Maleate

“…According to the method of Wakisaka et al (4), the anesthetized dog was laid on its back, and the cervical incision was made widely along the midline. All main arteries and their branches in the cervix were separated from the circumscribed tissues, and ligated except the right and left carotid artery.…”