Presented in this paper is the data from clinical laboratory examination of 50 Korean atomic-bomb survivors (Hiroshima and Nagasaki, Japan, 1945). Of them, 15 survivors were karyotyped from their lymphocyte culture for both “stable” and “unstable” types of chromosomal aberrations. Eight of their offspring were also tested for the chromosomal changes and SCE as well.The results are as follows:
All survivors were found to have suffered from various diseases, particularly from respiratory diseases. Two had malignancies, viz., one case having squamous cell carcinoma of uterine cervix and another, adenocarcinoma of stomach.Serum total protein and serum albumin levels were found to have decreased in 18% and 27% of the survivors, respectively. Alkaline phosphatase, SGOT, IgG and IgM increased in 22%, 6.3%, 36.7% and 13.6% of the survivors, respectively. IgA was within normal limit in all cases.Stable type of chromosomal aberrations was discovered in none of the survivors and the offspring examined. However, approximtely 50% of the survivors showed a significantly higher incidence of chromatid breakage than normal controls.None of the offspring showed the chromatid breakage, but 75% of them showed significantly higher rate of SCE when compared to controls.
From November 1981 to March 1984, 100 patients with esophageal varices bleeding were treated by endoscopic sclerotherapy.The combined peri and intravasal method was applied, using Äthoxysclerol as a sclerosant.The 79 cases were followed after sclerotherapy over a period ranging from 3 months to 26 months.The amount of transfused blood on presclerotherapy was 4–5 pints and in 2/3 cases 1–2 pints were needed on postsclerotherapy.Seven cases (8.1 per cent) had complications; 2 cases developed esophageal stenosis, 3 cases aspiration pneumonia, and 2 cases mediastinitis.Fortunately, all 7 cases recovered. Rebleeding occurred in 15 cases (19.0 per cent); namely 3 cases (3.8 per cent) within 6 months, 5 cases (6.3 per cent) in the period from 6 months to 12 months and 7 cases (8.9 per cent) after 12 months.During the follow up period, 14 cases died. Their causes of death were as follows: 6 cases died of hepatic failure, 5 cases died of hepatoma, and 3 cases expired from uncontrollable bleeding.Based on data, it appears to be possible to control the bleeding in 97 per cent of the esophageal varices bleeding on their (first) bleeding.
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