Gold nanorods (GNRs) are emerging as a promising nanoplatform for cancer theranostics because of their unique optical properties. However, they still suffer from many limitations, such as high cytotoxicity, low thermodynamic and biological stability, and a tedious process for integrating other imaging modalities, for further practical biomedical applications. In this work, a strategy by one-step coating of GdOS around GNRs is reported to address these limitations of GNRs. After the coating of the GdOS shell, the as-fabricated GdOS coated GNRs (GNRs@GdOS) show enhanced biocompatibility and photostability, and tunable localized surface plasmon resonance. The strong absorption in the near-infrared region renders GNRs@GdOS outstanding photoacoustic imaging and photothermal therapy capabilities. Moreover, owing to the T shortening ability of GdOS, the GNRs@GdOS also show an excellent T MRI contrast performance. The GNRs@GdOS thus can serve as a versatile nanoplatform for cancer theranostics combining dual-modal imaging and photothermal therapy.
The
UV plasmonic properties of Al shallow pit arrays (ASPA) are investigated
by experimental and simulative methods. ASPA with various periods
are fabricated by the hard anodization (HA) technique. The measured
reflectance spectra of ASPA exhibit a reflectance pit in the UV region,
which is red shifted with the increasing period of ASPA and refractive
index of the surrounding medium. The dependence of reflectance on
the period and refractive index calculated by the finite difference
time domain (FDTD) method exhibits the identical evolution trends
with measurement results. The angle-dependent reflectance spectrum,
spatial electric field, and surface charge distribution calculated
by FDTD reveal that ASPA sustains propagating surface plasmons (SPs),
the UV reflectance pit corresponds to the propagating SPs mode,
and the total field inside the Al shallow pit and its proximity region
is enhanced with increasing the period of ASPA, which reveals the
origin of the higher sensing performance of ASPA with bigger period
and is in accordance with the measured results.
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