Das Fragmentierungsverhalten der 4-Benzylisochinoline 2-8 nach Elektronenstofi-Ionisation wird beschrieben und mit dem der entsprechenden 1-Benzylisochinoline 1 verglichen. Der Verlust des o-standigen Benzylsubstituenten X in den Isochinolinen 3-8 fiihrt zu Signalen mittlerer bis hoher Intensitat. Eine eindeutige Unterscheidung zwischen den ortho-und meta-/para-Isomeren 5a-c/7a-c ist nur bei hohen Anregungsenergien moglich.
Mass Spectrometric Studies on Benzylisoquinolines: Electron Jmpact Jnduced Loss of the Benzyl SubstituentsThe modes of electron-impact induced fragmentation of the 4-benzylisoquinolines 2-8 are reported and compared with those of the isomeric I-benzylisoquinolines 1. Loss of the ortho substituents X in 3-8 gives rise to signals of medium to high intensities. High ionization energies make it possible to differentiate unequivocally between the ortho and meta/para isomers 5a-c/7a-c.
Die unter Aromatisierung verlaufende Benzylierung von Piperidin‐ bzw. Tetrahydroisochinolin‐Derivaten mit Benzaldehyden (Rügheimer‐Burrows‐Reaktion) ist eine vielstufige Reaktion, für die verschiedene Mechanismen diskutiert werden. Durch die Isolierung und Charakterisierung der nachfolgend beschriebenen Intermediate bzw. Nebenprodukte werden Teilschritte der Gesamtsequenz plausibel erklärbar.
Chromium compounds and hydrogen peroxide are usually identified by their reaction to form blue chromium oxide peroxide hydrate, which is extracted with diethyl ether as a co-ligand. Findings suggest that diethyl ether can be replaced without loss in analytical performance using solvents from the alcohol, arene, ester, ether, halogenated hydrocarbon, and ketone series. DFT calculations have been performed for several solvates. Results indicate that some of the solvates studied may exist as two rotamers.
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