IMPORTANCEThe benefit of high-dose dexamethasone and oxygenation strategies vs standard of care for patients with severe acute hypoxemic respiratory failure (AHRF) caused by COVID-19 pneumonia is debated.OBJECTIVES To assess the benefit of high-dose dexamethasone compared with standard of care dexamethasone, and to assess the benefit of high-flow nasal oxygen (HFNO 2 ) or continuous positive airway pressure (CPAP) compared with oxygen support standard of care (O 2 SC). DESIGN, SETTING, AND PARTICIPANTSThis multicenter, placebo-controlled randomized clinical trial was conducted in 19 intensive care units (ICUs) in France from April 2020 to January 2021. Eligible patients were consecutive ICU-admitted adults with COVID-19 AHRF. Randomization used a 2 × 3 factorial design for dexamethasone and oxygenation strategies; patients not eligible for at least 1 oxygenation strategy and/or already receiving invasive mechanical ventilation (IMV) were only randomized for dexamethasone. All patients were followed-up for 60 days. Data were analyzed from May 26 to July 31, 2021.INTERVENTIONS Patients received standard dexamethasone (dexamethasone-phosphate 6 mg/d for 10 days [or placebo prior to RECOVERY trial results communication]) or high-dose dexamethasone (dexamethasone-phosphate 20 mg/d on days 1-5 then 10 mg/d on days 6-10). Those not requiring IMV were additionally randomized to O 2 SC, CPAP, or HFNO 2 . MAIN OUTCOMES AND MEASURESThe main outcomes were time to all-cause mortality, assessed at day 60, for the dexamethasone interventions, and time to IMV requirement, assessed at day 28, for the oxygenation interventions. Differences between intervention groups were calculated using proportional Cox models and expressed as hazard ratios (HRs). RESULTS Among 841 screened patients, 546 patients (median [IQR] age, years; 414 [75.8%] men) were randomized between standard dexamethasone (276 patients, including 37 patients who received placebo) or high-dose dexamethasone (270 patients). Of these, 333 patients were randomized among O 2 SC (109 patients, including 56 receiving standard dexamethasone), CPAP (109 patients, including 57 receiving standard dexamethasone), and HFNO 2 (115 patients, including 56 receiving standard dexamethasone). There was no difference in 60-day mortality between standard and high-dose dexamethasone groups (HR, 0.96 [95% CI, 0.69-1.33]; P = .79). There was no significant difference for the cumulative incidence of IMV criteria at day 28 among O 2 support groups (O 2 SC vs CPAP: HR, 1.08 [95% CI, 0.71-1.63]; O 2 SC vs HFNO 2 : HR, 1.04 [95% CI, 0.69-1.55]) or 60-day mortality (O 2 SC vs CPAP: HR, 0.97 [95% CI, 0.58-1.61; O 2 SC vs HFNO 2 : HR, 0.89 [95% CI,). Interactions between interventions were not significant. CONCLUSIONS AND RELEVANCEIn this randomized clinical trial among ICU patients with COVID-19-related AHRF, high-dose dexamethasone did not significantly improve 60-day survival. The oxygenation strategies in patients who were not initially receiving IMV did not significantly modify 28-day risk of...
Since the 1970s, the excavations on Thasos have brought to light two inscriptions relating to the imperial family. The first, dated between 14 and 29 AD, is owed to Komis, the priestess of Livia. Engraved on the back face of the north-west portico, it was the dedication of the exedra in the west part of the agora. The second, completed by a fragment discovered in 2006, is the dedication of a statue for Agrippa Postumus, adoptive son of Augustus honoured as a benefactor in the ancestral tradition. The two texts attest to the transformations in monumentality and in Thasian society at the beginning of the Empire.
La publication de 22 nouvelles lignes d'un nouveau fragment du « Règlement sur les Braves » (J. POUILLOUX, Recherches sur Thasos I, 141), relatif aux funérailles des citoyens morts pour la patrie, ajoute trois clauses. La cité assurera l'entretien des orphelins de guerre en leur versant une allocation journalière, à condition qu'ils soient effectivement nécessiteux. Les fils des métèques recevront une indemnité forfaitaire de 17,5 statères. Les fils d'autres individus indéterminés (nothoi ?, affranchis ?) se contenteront de privilèges définis dans un décret antérieur. La publication est prévue près du prytanée. Le document apporte plusieurs nouveautés, comme l'existence de prytanes. Il permet de réexaminer la question des dénominations monétaires dans le nouveau système introduit à Thasos, au début du IVe s. L'ensemble du règlement trahit la forte influence du modèle athénien. Il fut adopté dans des circonstances militaires exceptionnelles, dans lesquelles il faut sans doute reconnaître la désastreuse guerre de Datos/Krénidès, en 360-356 av. J.-C.
Herodes son of Samos and his family. About a funerary inscription reused in the northern basilica at the site of Hagios Vassileios (Thasos). Among the significant finds at the site of Hagios Vassileios, to the west of the ancient city of Thasos, is the base of an ambon which belongs to northern most paleochristian basilica brought to light in this area. In an older phase, the block belonged to an inscribed funerary monument : five names, among which three are male and two female, were engraved on its main face. All these names appear in other Thasian inscriptions of Roman times : they belong to an important local family, in which the names Herodes son of Samos and Samos son of Herodes seem to have alternated from generation to generation. The confrontation of these documents allows a reconstruction of the stemma of the family as well as the study of its integration into the upper class of Thasian society.
Η ανασκαφή του 2004 στις βόρειες παρυφές του Αρτεμισίου της Θάσου οδήγησε στην ανακάλυψη ενός σπαράγματος ψηφίσματος προς τιμήν του Στίλβωνος από τη Θάσο, το οποίο χρονολογείται ανάμεσα στον 1ο αι. π.Χ. και στον 1ο αι. μ.Χ. Ο Στίλβων προσφέρθηκε να χρηματοδοτήσει τις οικοδομικές εργασίες και τις επισκευές στο ιερό μιας θεάς της πόλης. Το κείμενο, το οποίο έχει συνταχθεί σε ύφος ελάχιστα συμβατικό, δείχνει πώς εξελίχθηκε η συντήρηση των θρησκευτικών εγκαταστάσεων, η ευθύνη της οποίας πέρασε από την πολιτεία στους πλούσιους ιδιώτες.
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