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Balloon catheter-based accelerated partial breast irradiation (APBI) may result in desirable shortterm outcomes in patients undergoing breast conserving surgery. Design: Prospective consecutive case series. Setting: Tertiary multidisciplinary referral center. Patients: Forty selected patients with invasive breast carcinoma undergoing breast conserving surgery and Mam-moSite device placement. Interventions: Breast conserving surgery, sentinel and/or axillary node dissection, placement of the new balloon catheter applicator (MammoSite device), and APBI. Main Outcome Measures: Infection, early and late seroma, device explantation, time to initiating APBI, acute toxic effects on the skin, and cosmesis using the Harvard Scale.

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