5(3)-Amino-3(5) phenylpyrazoles 3a-f have been conveniently prepared by condensation of a-oxoketene O,N-acetals 2a-g with hydrazine using montmorillonite K-10 as solid support under sonication.
A series of a-bromo 3-amino-5,5-dimethylcyclohex-2en-1-ones 2a-g and a-bromo b-enamino compounds 4a, b have been conveniently prepared using NBS supported on montmorillonite (K-10). Other reaction conditions such as di-tert-butyl peroxide/NBS/CCl 4 , and Br 2 /CH 2 Cl 2 were also studied for 3-amino-5,5dimethylcyclohex-2-en-1-ones 1b, e, g resulting in a mixture of mono and di-brominated compounds 5b, f, g and 6b, e, g.
halogenation halogenation O 0235 06 -047 α-Bromination of β-Enamino Compounds Using K-10.-β-Enaminoketones (I) and (III) dispersed on montmorillonite K-10 are conveniently brominated by NBS to form α-bromo derivatives (II) and (IV). Other reaction conditions give a mixture of mono-and di-brominated compounds (II) and (V) or, in the case of allylated substrate (Id), the tribromo derivative (VI). -(BRAIBANTE, MARA E. F.; BRAIBANTE, HUGO T. S.; ROSSO, GIOVANNI B.; DA ROZA, JULIANO K.; Synthesis (2001Synthesis ( ) 13, 1935Synthesis ( -1937 Dep. Quim., Univ. Fed.
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