Synthesis of Aminopyrazoles from α‐Oxoketene O,N‐Acetals Using Montmorillonite K‐10/Ultrasound.

Braibante, Mara Elisa Fortes; Braibante, Hugo T. S.; Roza, Juliano K. da; Henriques, Danielle M.; Tavares, Luciana de Carvalho

doi:10.1002/chin.200341124

Cited by 2 publications

(2 citation statements)

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“…5-Amino-3-phenylpyrazoles 44 were prepared from α-oxoketene O , N -acetals 43 using montmorillonite K-10 under sonication conditions [ 23 ]. The cyclocondensation of non-symmetrical enaminodicketones 46 on various hydrazine derivatives has been studied in the case of tert -butylhydrazine and carboxymethylhydrazine.…”

Section: The Main Methods Of Access To the Pyrazole Nucleusmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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Section: The Main Methods Of Access To the Pyrazole Nucleusmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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“…All the chemical reagents were purchased from commercial sources and used as received unless otherwise indicated. Compounds 1a, 17 3i, 18 and 7a 10b are known, and their spectroscopic features are in good agreement with those reported in the literature.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Copper(II)-Mediated Intramolecular Cyclopropanation of Ketene N,X-Acetals (X = S, O, N) under Mild Conditions

Huang

2020

J. Org. Chem.

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CuBr2-mediated intramolecular oxidative cyclopropanation of α-oxo ketene N,S-acetals was efficiently achieved to afford 2-thioalkyl-3-azabicyclo-[3.1.0]hexenes under mild conditions. 2-Oxyalkyl- and 2-aminoallyl-3-azabicyclo-[3.1.0]hexenes were also obtained from the corresponding α-oxo ketene N,O- and N,N-acetals. Further C–S bond transformations led to diverse 2-aryl-substituted 3-azabicyclo[3.1.0]hexene derivatives in good to high yields.

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Synthesis of Aminopyrazoles from α‐Oxoketene O,N‐Acetals Using Montmorillonite K‐10/Ultrasound.

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 2 publications

References 1 publication

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

Copper(II)-Mediated Intramolecular Cyclopropanation of Ketene N,X-Acetals (X = S, O, N) under Mild Conditions

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