Conflito de interesses:Não Contribuição dos autores: JCS coleta, tabulação, delineamento do estudo e redação do manuscrito. JRCM orientação do projeto, delineamento do estudo e elaboração do manuscrito. LLF orientação do projeto, delineamento do estudo, elaboração do manuscrito e análise estatística. OMC orientação do projeto, delineamento do estudo e elaboração do manuscrito. JRJ coleta de dados e discussão dos achados. JIPSF coleta de dados e discussão dos achados. Contato para correspondência: Jaqueline Cortezia de Souza E-mail: jaqueline.cortezia@hotmail. Abstract Introduction:Invasive mechanical ventilation provides ventilator support, especially for those with acute respiratory failure. The objective is to maintain the respiratory function; however, it is essential to stop it as soon as possible in order to avoid its deleterious effects. Therefore, the ideal solution is to plan weaning and extubation as early as possible. Several factors may interfere with the success and failure of the patient's withdrawal from invasive mechanical ventilation. One of these factors includes fluid balance, which is the ingestion, elimination, and redistribution of fluid throughout the body, regulating renal and pulmonary functions. Objective: Verify the water balance interference in the outcome of weaning from mechanical ventilation of adult patients hospitalized in an intensive care unit. Patients and Methods: This is a prospective non-randomized longitudinal study, conducted at the Hospital de Base in São José do Rio Preto, inland of São Paulo State. Inclusion criteria were patients of both sexes, aged 18 and over undergoing invasive mechanical ventilation over 72 hours, and admitted from May to November 2016. Patients also presented absence or minimal doses of vasoactive drugs and underwent respiratory tests to be elected to weaning and extubation. Normal distribution data was confirmed by a Kolmogorov-Smirnov test. Comparison of the sum of water balance values in pre-extubation with the balance values 24 hours after extubation was assessed by unpaired t test. We considered p ≤ 0.05 as significant. Results: Data were collected from 30 patients. Of these, the clinical status of 10 individuals (33%) evolved to weaning and extubation. Both groups had a positive water balance and there was no significant difference between them. Conclusion: We concluded that the positive water balance did not interfere in the outcome of weaning from mechanical ventilation.
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