Riedel’s thyroiditis is a rare entity consisting of a fibrotic process of the thyroid which can generate gland destruction, infiltration of cervical structures and even airway obstruction. It has been associated with systemic fibrotic disorders, autoimmune diseases, and more recently with spectrum of diseases related to excess of Immunoglobulin G type 4 (IgG4). Two cases of Riedel’s thyroiditis by IgG4, confirmed by immunohistochemistry and was managed surgically with favorable results during the follow-up time, are presented. These case descriptions highlight the diagnostic challenge of this disease, describe the response with surgical management, and make a brief update on the subject.

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Durante a crise política de 2005, os blogs de política, principalmente os mantidos por jornalistas conhecidos na mídia, tornaram-se um novo campo de informação e debate. Neste artigo, nossa intenção é apresentar os dados preliminares de extensa pesquisa sobre os blogs de política, baseada na observação sistemática, ao longo dos anos de 2005 e 2006, dos principais exemplos brasileiros. O foco, aqui, será a natureza do debate público que envolve autores e leitores, procurando analisar sua dinâmica e relacioná-la com as expectativas teóricas que vêem na internet um ambiente comunicativo capaz de incentivar a pluralidade política e a deliberação discursiva.

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Background and aim:We describe two cases of pseudoxanthomatous salpingitis (PXS), an uncommon entity, often unknown for clinicians and pathologists. We review the literature on this topic and perform immunohistochemistry in order to study its pathogenesis. Methods: Both cases are studied by histochemical and immnunohistochemical methods with a wide panel of antibodies. Results: One case showed bilateral PXS, ovarian endometriosis and an adenomatoid tumor in the right tube. The second case showed a unilateral focus of tubal endometriosis. The first case displayed pigmented histiocytes, positive with periodic acid-Schiff (PAS), PAS with diastase digestion and focally with Fontana-Masson stains. Abundant hemosiderin granules were present in stromal subepithelial cells but no in histiocytes. In the second case Fontana-Masson and Ziehl-Neelsen methods stained diffusely the histiocytes. Perls stain was positive in some stromal cells and in numerous granular macrophages. The lymphocytic infiltrates presented mainly T cells with different proportions of CD4 and CD8 lymphocytes in each case. The tubal stroma was positive for CD10 in both cases. Conclusions: PXS is a rare condition usually associated with ovarian endometriosis. The physiopathologic way of pseudoxanthomatous histiocytes to accumulate inside the plicae of the tubes is not clear and can be diverse in different cases.

Perflubron (perfluoroocytlbromide, PFOB) emulsion concentrations of 100%, 90%, or 60% w/v were administered to mice with and without 3 types of murine malignant tumor implants, and the distribution in blood, tumor, lung, liver and spleen were studied 48 hours after a dose of 10 or 3 g/Kg of PFOB. The most important changes were seen in the blood where the PFOB concentration [PFOB] was decreased in tumor bearing mice (TBM). Blood [PFOB] was also decreased in TBM and normal mice (NM) that received the 60% emulsion. Liver [PFOB] was increased in TBM. Lung [PFOB] was directly proportional to the emulsion concentration with the 10g/Kg dose. No major differences were seen in the biodistribution between the 100% and 90% emulsions using 10g/Kg, in spite of differences in composition and manufacturing history.

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lesions: right inferior lobe (4mm), medial segment (6 mm), lateral segment (9mm) spiculated with pleural tail and left adrenal gland (11mm). The patient refers weight loss (6kg) but denies respiratory symptoms. Chest surgery performs lung resection by thoracoscopy, obtaining a 12mm nodule with retraction of visceral pleura in the right inferior lobe. Pathology reports a typical CT, KI67 4%, low-grade neuroendocrine tumor, well differentiated, grade 1. A right inferior lobectomy was done by thoracoscopy with mediastinal lymphadenectomy. Pathology described the morphological pattern and immunophenotypical profile of an AAH. No residual CT was found. Conclusion: AAH has been described as a putative lesion preceding lung AC (OR 2.97; 95% CI 1.82-4.85). However, previous case-series of patients with resected lung for primary lung carcinoma found AAH in other primary lung tumor subtypes, including 3.3% patients with lung CT2. To our knowledge, this is the first case described of a typical CT with a concomitant finding of AAH. Further studies are required in larger samples to confirm this finding. Despite the strong association between AAH and AC, it must be considered as a histopathological finding in the context of other primary lung neoplasms, such as the typical CT.