An eight-year-old male patient was admitted to the hospital with a history of left median paramedian frontal craniectomy due to car trauma at six months of age. Axial computed tomography of the skull with reconstruction in three dimensions revealed an arachnoid cyst with slight herniation of the brain in the frontal lobe, leading to protrusion against the skullcap, causing dilation of the ex-vacuum of the anterior extension of the homolateral lateral ventricle. He presented asymmetrical lateral ventricles, a reduced base cistern, and a slightly ectatic IV centred ventricle. After the physical examination, no neurological deficit was found, despite the changes identified in the images. It is believed that such conditions may progressively worsen with the development and maturation of nervous tissue over the age of the assessed child. To confirm this, specialized monitoring is of fundamental importance.

Background and aims:Diabetes affects the metabolism promoting damage in different tissues, including salivary glands. Current treatments, such as insulin, are ineffective to recovery of these tissues. In this aspect, the immunotherapy has been tested, but it can be inefficient as an agent for the control of damage caused by diabetes. The aim of this study to evaluate the association in anti-CD4 and anti-CD8 monoclonal antibody in the recovery of salivary glands of diabetic NOD mice. Material and methods: Fifteen spontaneously diabetic mice (NOD) were divided into three groups with 5 animals each: group I (Balb/C control mice), group II (untreated NOD mice), group III (NOD mice treated with CD4 and CD8 antibodies). The CD4 and CD8 antibodies (IMUNY, Rheabiotech Ltda, Brazil) were administered by intravenously injections (25 ug/days: 0, 7, 14, and 21). After treatment salivary glands samples were analyzed by immunofluorescence, microscopy, light microscopy and stereology. (ethical approval process: 304/11), Analysis of variance (ANOVA) and Kruskal-Wallis nonparametric test were used. Results: Elevated levels of glucose (mg/dl) were observed in untreated animals (group II) (605.25 ± 31.23, p≤0.05), whereas in treated animals (group III), were noted a decrease in these levels (464.77 ± 39.66, p≤0.05). Tissue restructure, characterized by cell volume recovery, also was observed in group III (nuclear volume of parotid glands: (109.91 ± 02.03, p≤0.05) and submandibular glands: (107.52 ± 02, p≤0.05) (cytoplasmic volume of parotid glands: (356.14 ± 26.34, p≤0.05) and submandibular glands: (331.22 ± 32.11, p≤0.05). Intense signaling (+++) of insulin receptors was observed in animals of group I. On the other hand, in group II was noted a reduction of these receptors (+). In treated animals (group III) were observed a recovery of the insulin receptors (+++). Conclusions: This treatment was effective in the recovery of salivary acinar cells, contributed also to homeostasis of body metabolism. Thus, this immunomodulation promoted a beneficial effect on the recovery of these tissues. key words: anti CD4 and CD8, immunotherapy, salivary glands, diabetes mellitus 157 25. Robinson CP. Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjogren syndrome. Proc Natl Acad Sci 94 (11): 5767-71, 1997 26. Wildenberg ME, Van Helden-Meeuwsen CG, van de Merwe JP, Moreno C, Drexhage HA, Versnel MA. Lack of CCR5 on dendritic cells promotes a proinflammatory environment in submandibular glands of the NOD mouse. J Leukoc Biol 83(5): 1194-200, 2008 27. Markopoulos AK, Belazi M. Histopathological and immunohistochemical features of the labial salivary glands in children with type I diabetes. 29. Parish N, Cooke A. Characterisation of CD8 monoclonal antibody-induced protection from diabetes in NOD mice. Autoimmunity 38(8): 597-604, 2005 30. Yagi H, Matsumoto M, Kunimoto K, Kawaguchi J, Makino S, Harada M. Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes...

Objective: The objective of this study was to evaluate the incidence of placental abruption (PA) among nulliparous and multiparous women in the city of Dourados-MS Brazil. Materials and methods: Retrospective single-center cross-sectional study. 240 examinations of patients submitted to ultrasonography (USG) with medical indications for investigating PA were evaluated. Results: The average age was 28.6 ± 6.38, minimum 15 and maximum 43 years. The patients’ weeks of pregnancy showed an average of 7.8 ± 3.1 minimum 4 and maximum 27 weeks. PA occurred in 66 (27.7%) of the patients out of the 240 evaluated patients. Conclusion: The occurrence of PA in the studied population was high. There was no correlation between the occurrence of PA and the age of the patients. The relevance of family planning and adequate prenatal care in the early identification of risk factors for PA, as both contribute to reducing the incidence of unfavorable pregnancy outcomes.

OBJETIVO: Analisar o impacto da pandemia da COVID-19 no estilo de vida na população afetada pelas regras de distanciamento social.MÉTODOS: Trata-se de um estudo observacional e descritivo. A coleta dos dados ocorreu de forma não-probabilística, global, aleatória e voluntária através da aplicação do formulário Google Forms via internet, que foi elaborado em três idiomas com perguntas: referentes à/ao: idade, sexo, país de origem e tempo de distanciamento social; sobre a avaliação do estilo de vida; estruturadas de acordo com o questionário FANTASTIC. As análises estatísticas utilizadas foram os testes qui-quadrado, Shapiro-Wilk, teste t não-pareado, Mann-Whitney, ANOVA, Kruskal-Wallis e post-hoc de Bonferroni. Para todas as análises assumiu-se um p≤0,05.RESULTADOS: Do total de 475 pessoas que responderam ao questionário, 65,89% (313) estavam em distanciamento social. A maioria dos voluntários encontravam-se na categoria muito bom, e os domínios atividade física, nutrição, tipo/padrão de comportamento, introspecção e trabalho/satisfação com a profissão tiveram os menores valores médios nos grupos, o que impactou negativamente na classificação das categorias.CONCLUSÕES: A pandemia do COVID-19 tem afetado o estilo de vida da população, sendo necessárias medidas estratégicas de adoção e de conscientização nos diferentes aspectos que compõem um melhor estilo de vida, evitando assim consequências futuras negativas na saúde física e emocional da população pós-pandemia.

Mucinous ovarian cystadenoma is a benign tumor, which accounts for 15% of all ovarian tumors and, when diagnosed, 80% are benign, 10% limitrophe and 10% malignant. It is a cyst that arises from the ovary surface epithelium, presenting multilocular feature with plain surface. It is more common between 30- and 50-years old persons and clinical signs differ from other ovarian pathologies because they present rapid growth, reach large dimensions and evolve with peritoneal pseudomyxoma, causing a significant increase in abdominal volume. Imaging methods such as ultrasonography and computed tomography, as well as the tumor markers CA-125 and CEA, are fundamental for its elucidation and therapeutic planning. We report a case of giant mucinous cystadenoma of the left ovary in a 61-year-old patient admitted to the emergency room.