Female androgenetic alopecia is one cause of alopecia in women, although the ideal treatment for this condition remains far from defined. The objective of this study was to evaluate the efficacy and safety of intradermal injections with 0.5% minoxidil for the management of female androgenetic alopecia in a randomized, placebo‐controlled trial. A total of 54 women diagnosed with female androgenetic alopecia were divided into two groups: one group received intradermal injections of 0.5% minoxidil, and the other received 0.9% saline. Biopsy, trichogram, Trichoscan (Tricholog GmbH, Freiburg, Germany), and self‐assessment findings were used to evaluate the outcomes of treatment with minoxidil. In the treated group, there was a significant increase in the terminal‐to‐vellus hair ratio (P < .001) and in the percentage of anagen hairs (P = .048) and an improvement in hair loss and volume (P = .021 and P = .028, respectively). These results show that intradermal injections with minoxidil were more effective than placebo (P < .001) in the treatment of female androgenetic alopecia with a good safety profile.
Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered
to be a clinical variant of lichen planopilaris. It predominantly occurs in
postmenopausal women and has a slowly progressive course. It was first described
by Kossard in 1994. Since then the number of reported cases has increased
significantly. Coexistence of frontal fibrosing alopecia and autoimmune
disorders - such as discoid erythematosus lupus and Sjögren's syndrome -
may suggest a common pathogenic background among the diseases.
Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the
acrosyringial portion of the eccrine duct. Malignant transformation of
hidroacanthoma simplex is reported in the literature and the treatment is
performed with wide excision or Mohs micrographic surgery. We report the first
case successfully treated with cryosurgery with a long-term follow up.
We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and
severe neutropenia, who developed skin ulcers under cardiac monitoring
electrodes. The diagnosis of primary cutaneous aspergillosis was made after the
second biopsy and culture. Imaging investigation did not reveal internal fungal
infection. The child was treated, but did not improve and died 3 months after
admission. The report highlights and discusses the preventable risk of
aspergillus skin infection in immunocompromised patients.
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