Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

Uzel, Barbara Pontes Cerqueira; Takano, Gustavo Henrique Soares; Chartuni, Juliana Cabral Nunes; Cesetti, Mariana Vicente; Gavioli, Camila Fátima Biancardi; Lemes, André Moreira; Costa, Izelda Maria Carvalho

doi:10.1111/dth.14622

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…As for FPHL, sessions of mesotherapy using the same mixture also showed significant improved in hair parameters 8 . Recently, another clinical trial focusing on FPHL was finished 21 . It achieved a similar result that mesotherapy applying minoxidil led to hair growth improving but hair loss lessening.…”

Section: Resultsmentioning

confidence: 85%

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Current application of mesotherapy in pattern hair loss: A systematic review

Tang

Wang

et al. 2022

J of Cosmetic Dermatology

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Mesotherapy is defined as a non-surgical, minimally invasive procedure through intradermal or subcutaneous injection so that the drugs can step over the stratum corneum barrier and directly affect tissues rapidly, enhancing the pharmacological efficacy. 1 Since French physician Michel Pistor reported a case that he accidentally recovered a half-deaf patient's hearing transiently in the 1950s, the term "mesotherapy" has been created, linking the Greek words "mesos" meaning "middle" or "mean" and "therapeia" meaning "to treat medically." 2 Pistor founded the French Society of Mesotherapy in 1964Mesotherapy in , and, in 1987, The French National Academy of Medicine acknowledged mesotherapy as a medical treatment. 2 Nowadays, mesotherapy has been widely used in cosmetic dermatology, treating facial aging, cellulite, musculoskeletal pain, and alopecia in countries, and most of them present excellent

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Section: Resultsmentioning

confidence: 85%

“…8 Recently, another clinical trial focusing on FPHL was finished. 21 It achieved a similar result that mesotherapy applying minoxidil led to hair growth improving but hair loss lessening.…”

Section: Effectiveness In Phlmentioning

confidence: 80%

Current application of mesotherapy in pattern hair loss: A systematic review

Tang

Wang

et al. 2022

J of Cosmetic Dermatology

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“…8,11 The active agents-minoxidil, growth factors, panthenol, biotin, finasteride or dutasteride, and even steroids-delivered through multiple injections directly into the affected sites are already administered through other routes. 11,12 Uzel et al showed that a 10-week course of intradermal 0.5% minoxidil solution for FPHL was superior to a placebo with no significant side effects. 12 The suggested weekly frequency of the procedure may limit the patient's compliance with mesotherapy.…”

Section: Mesotherapy/intradermal Injectionsmentioning

confidence: 99%

“…11,12 Uzel et al showed that a 10-week course of intradermal 0.5% minoxidil solution for FPHL was superior to a placebo with no significant side effects. 12 The suggested weekly frequency of the procedure may limit the patient's compliance with mesotherapy.…”

Section: Mesotherapy/intradermal Injectionsmentioning

confidence: 99%

Minimally invasive procedures for the management of female pattern hair loss

Melo

Almeida

Frattini

et al. 2022

J of Cosmetic Dermatology

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Background Female Pattern Hair Loss (FPHL) is one of the most common types of hair loss in women. It is characterized by progressive follicular miniaturization leading to diffuse hair thinning over the midfrontal scalp with a negative impact on quality of life. Pharmacological treatments are commonly used, and hair follicle transplantation is an option for those cases with adequate donor area. Minimally invasive procedures, such as microneedling, mesotherapy, microinfusion of drugs into the scalp with tattoo machines (MMP®), and platelet‐rich plasma (PRP) have been reported as adjuvant treatments. Aims This study aims to summarize and discuss the efficacy of minimally invasive procedures described for the management of FPHL. Methods Published articles indexed on the Pubmed database and Scopus that described minimally invasive procedures for the management of FPHL in humans were considered. Citations were reviewed and added for completeness. The search was for articles in English only. After excluding duplicate titles, 23 relevant articles were considered. Conclusion Minimally invasive procedures are promising options and may play a role in FPHL treatment. They can be used as adjunctive therapy for FPHL, in case of poor response to clinical therapy, or when patients prefer other care than the standard. We reinforce that these methods should be performed by an experienced medical professional following strict aseptic techniques. However, microneedling, mesotherapy, MMP, and PRP lack standardization and are supported by a low level of evidence yet. For the future, larger randomized clinical trials are essential to determine the efficacy and optimal protocols for these treatments.

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“…Although minimally invasive, mesotherapy may be related to mild side effects like burning, erythema and headaches, as a few reports indicate. Among the most serious adverse events, hair loss at injection sites, subcutaneous necrosis, scalp abscesses, and angioedema have been described 8–10 …”

Section: Variables Categories Statisticsmentioning

confidence: 99%

Frontal edema due to mesotherapy for androgenetic alopecia: A case series

Melo

Saceda‐Corralo

Tosti

et al. 2021

Dermatologic Therapy

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Androgenetic alopecia (AGA) is the most common form of non-cicatricial alopecia in both genders. Currently approved drugs for the treatment of AGA include topical minoxidil in women and topical minoxidil and oral finasteride in men. Other routes of administration of approved drugs have been proposed to enhance therapeutic results for AGA, including intradermal injections, known as mesotherapy. Mesotherapy-or intradermotherapy-is a non-surgical procedure, consisting of multiple intradermal injections of pharmacological substances diluted in small doses. Although minimally invasive, mesotherapy may be related to mild side effects like burning, erythema and headaches, as a few reports indicate. Among the most serious adverse events, subcutaneous necrosis, scalp abscesses, and angioedema have been described. This multicenter retrospective, descriptive study aims to report 14 cases of frontal edema resulting from mesotherapy for AGA treatment. In our patients, the edema mostly arose in the first two sessions and lasted between 1 and 4 days, with a favorable outcome after a local cold compress. In all our cases of edema, lidocaine was the anesthetic used. Minoxidil and dutasteride might also play a role as causative agents. To the best of our knowledge, this is the largest case series focused on frontal edema after mesotherapy for AGA and gives clinicians helpful information for when performing this technique. Dermatologists should already consider and be conscious of this possible mesotherapy side effect, as it can be remarkably disruptive to affected patients.

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Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

Cited by 17 publications

References 24 publications

Current application of mesotherapy in pattern hair loss: A systematic review

Current application of mesotherapy in pattern hair loss: A systematic review

Minimally invasive procedures for the management of female pattern hair loss

Frontal edema due to mesotherapy for androgenetic alopecia: A case series

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