Background: Therapeutic hypothermia (TH) is standard-of-care for infants with moderate and severe HIE in developed countries; TH has been shown to decrease the risk of brain injury in asphyxiated newborns. Observations were like: 1) Asses morbidity and mortality in neonates with moderate and severe birth asphyxia treated with TH and 2) Asses neurological outcome in neonates.Methods: A RCT was done in NICU of Balchikitsalaya, RNTMC, Udaipur. Phase changing material, FS 21, FS 29 used to provide TH for 72 hours, started within 6 hours of birth and neurological outcome was assessed.Results: Total 60 neonates were enrolled 30 cases given TH and 30 control not given TH. Neurological assessment on basis of Thompson scoring, done on admission, 24, 48, 72 and 96 hours for both groups. At 48 hours, mean score in controls 14.5±1.67 and cases 11.47±2.34 (p<0.05). At discharge, mean score for controls was 11.31±3.67 and for cases was 5.24±2.72 (p<0.005). Mortality was 4 (13.3%) in cases and 11 (36.7%) in control group. Among 45 survivors, 25 (55.5%) required anticonvulsant at discharge; 15 from controls, 10 from cases group.Conclusions: There was significant decrease in mortality in birth asphyxia babies given TH as compared to babies not given TH. Also, significant improvement in Thompson score among the cooled neonates at and after 48 hours of age suggestive of better immediate neurological outcome in these babies. Anticonvulsant’s requirement was also significantly less in therapeutic hypothermia group.
Background: Low birth weight (LBW) contributes substantially to neonatal, infant and childhood morbidity as well as mortality. Across the world neonatal mortality is 20 times more likely for low birth weight babies compared to heavier babies (>2.5 kg). Proportion of LBW babies at birth in Rajasthan is 14%. The present study is proposed to explore the determinants of LBW in babies admitted at tertiary care hospital. The objective of the study was to study the clinic-epidemiological profile and outcome of LBW neonates; to study various factors associated with LBW.Methods: This study was a hospital based descriptive cross-sectional study, carried out at NICU of MBGH, R.N.T Medical College, Udaipur, Rajasthan. The study population comprised of all LBW babies delivered in medical college attached hospital and admitted in NICU, for duration of one year from September 2019 to august 2020. Total 350 babies were enrolled in study as per calculated sample size.Results: LBW was found to be associated with low maternal age, low level of mother education, maternal anemia, less BMI, stature of mothers, number of ANC visits, poor maternal weight gain during pregnancy, per-capita income, etc. Most common cause of mortality was found in LBW was septicemia and of morbidity was RDS.Conclusions: The identified risk factors in our study were modifiable and many were preventable. Maternal age, education of mothers, nutrition of mothers, anaemia status, number of ANC visits by mothers are preventable causes. Demographic profile, socio-economic status; many medical and obstetric factors are modifiable.
Osteogenesis imperfecta (OI) is a group of rare inherited disorders of connective tissue with the hallmark of excessive fragility of bones caused by mutations in collagen characterized by remarkable soft and large cranium and short-curved limbs. Radiological findings, such as, under mineralization of skull, platyspondyly, severely short and deformed long bones, and small continuously beaded ribs, pathognomonic for OI, were observed. Considering the clinical/radiological manifestations, a diagnosis of OI was made.
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