Summary. In acute carbon tetrachloride-induced liver damage in rats, plasma iron and total iron-building capacity were enormously elevated. This was coupled with an increase in the weight of livers and spleens as well as spleen iron concentrations when compared with control values. On the other hand, the haematocrit and liver iron concentrations were low. In chronic liver injury there were no changes in plasma iron or total iron-binding capacity. The gains in weight of both liver and spleen were dependent upon the dose of hepatic poison. Liver iron stores were also increased; however, this increase was attributable to the expansion of haemosiderin iron. In Grade III cirrhosis, the rate of iron absorption dropped significantly, possibly as a result of increased liver stores.
The hydrolysis of acetylsalicylic acid (ASA) in vivo by serum and various
tissues of rats with experimentally produced acute and chronic toxic liver damage, was
estimated by spectrophotometric measurement of salicylic acid (SA) appearance. It was
inferred from the data obtained that the liver tissue helped to maintain normal ASA
esterase activity in the blood which would otherwise be affected by liver damage.
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