Tissue Iron in Acute and Chronic Liver Damace From Carbon Tetrachloride

Abstract

Summary. In acute carbon tetrachloride-induced liver damage in rats, plasma iron and total iron-building capacity were enormously elevated. This was coupled with an increase in the weight of livers and spleens as well as spleen iron concentrations when compared with control values. On the other hand, the haematocrit and liver iron concentrations were low. In chronic liver injury there were no changes in plasma iron or total iron-binding capacity. The gains in weight of both liver and spleen were dependent upon the dose of hepatic poison. Liver iron stores were also increased; however, this increase was attributable to the expansion of haemosiderin iron. In Grade III cirrhosis, the rate of iron absorption dropped significantly, possibly as a result of increased liver stores.

Tissue Acetylsalicylic Acid Esterase Activity in Rats with Acute and Chronic Liver Damage from Carbon-Tetrachloride and Ethanol

“…A grade III cir rhosis [3] was detected in the CCl4-treated rats and a moderate fatty change was found in the chronic alcoholic rats. The total liver lipids of the alcoholic group of rats were found to be 67 ±16.2 mg/g dry weight as compared to 27 ±5.6 mg/g dry weight in the control group.…”