The formation of new bonds is pivotal in organic chemistry and a prerequisite to life because it allows the construction of complex molecules from simple precursors.
Active
metabolites from natural sources are the predominant molecular
targets in numerous biological studies owing to their appropriate
compatibility with biological systems and desirable selective toxicities.
Thus, their potential for therapeutic development could span a broad
scope of disease areas, including pathological and neurological dysfunctions.
Cardiac glycosides are a unique class of specialized metabolites that
have been extensively applied as therapeutic agents for the treatment
of numerous heart conditions, and more recently, they have also been
explored as probable antitumor agents. They are a class of naturally
derived compounds that bind to and inhibit Na+/K+-ATPase. This study presents cardiac glycosides and their analogues
with highlights on their applications, challenges, and prospects as
lead compounds for cancer treatment.
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