As traightforward ande fficienti odine-promoted ring-opening/cyclization domino reaction of 1-cyanocyclopropane 1-esters for the synthesiso ff ully substituted 2-aminofurans is reported. This reaction involvest he sequential ring-opening/intramolecular cyclization reactiono f1 -cyanocyclopropane 1-esters to give the corresponding 2-amino-4,5-dihydrofurans, which were oxidized with I 2 and Et 3 Ni nr efluxing toluene to give the corresponding 2-amino-3-furancarboxylates.
An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds.
An efficient and straightforward the preparation of 6-carbamoylfulvene-6-carboxylates via a cycloaddition reaction between 1-cyanocyclopropane 1-ester and β-nitrostyrenes.
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