BACKGROUND AND PURPOSE:The PED is a flow-diverting stent designed for the treatment of cerebral aneurysms. We report 4 cases of delayed ipsilateral IPH following the technically successful treatment of anterior circulation aneurysms with the PED.

In this independent study, the Pfirrmann classification demonstrated an adequate agreement among different observers and by the same observer on separate occasions. Furthermore, it allows communication between radiologists and spine surgeons.

Multiple Sclerosis patients' clinical symptoms do not correlate strongly with structural assessment done with traditional magnetic resonance images. However, its diagnosis and evaluation of the disease's progression are based on a combination of this imaging analysis complemented with clinical examination. Therefore, other biomarkers are necessary to better understand the disease. In this paper, we capitalize on machine learning techniques to classify relapsing-remitting multiple sclerosis patients and healthy volunteers based on machine learning techniques, and to identify relevant brain areas and connectivity measures for characterizing patients. To this end, we acquired magnetic resonance imaging data from relapsing-remitting multiple sclerosis patients and healthy subjects. Fractional anisotropy maps, structural and functional connectivity were extracted from the scans. Each of them were used as separate input features to construct support vector machine classifiers. A fourth input feature was created by combining structural and functional connectivity. Patients were divided in two groups according to their degree of disability and, together with the control group, three group pairs were formed for comparison. Twelve separate classifiers were built from the combination of these four input features and three group pairs. The classifiers were able to distinguish between patients and healthy subjects, reaching accuracy levels as high as 89% ± 2%. In contrast, the performance was noticeably lower when comparing the two groups of patients with different levels of disability, reaching levels below 63% ± 5%. The brain regions that contributed the most to the classification were the right occipital, left frontal orbital, medial frontal cortices and lingual gyrus. The developed classifiers based on MRI data were able to distinguish multiple sclerosis patients and healthy subjects reliably. Moreover, the resulting classification models identified brain regions, and functional and structural connections relevant for better understanding of the disease.

BACKGROUND AND PURPOSE:The PED is an FDS designed for the treatment of intracranial aneurysms. Data regarding the use of this device in acute or subacute aSAH is limited to a few case reports or small series. We aimed to demonstrate the feasibility of using an FDS, the PED, for the treatment of ruptured intracranial aneurysms with challenging morphologies.

Endovascular treatment with the pipeline flow-diverting stent may be a viable treatment option for otherwise difficult-to-treat aneurysm morphologies in the context of acute SAH.

SUMMARY:Complications of endovascular therapy of aneurysms mainly include aneurysm rupture and thromboembolic events. The widespread use of MR imaging for follow-up of these patients revealed various nonvascular complications such as aseptic meningitis, hydrocephalus, and perianeurysmal brain edema. We present 7 patients from 5 different institutions that developed MR imagingenhancing brain lesions after endovascular therapy of aneurysms, detected after a median time of 63 days. The number of lesions ranged from 4 -46 (median of 10.5), sized 2-20 mm, and were mostly in the same vascular territory used for access. Three patients presented with symptoms attributable to these lesions. After a median follow-up of 21.5 months, the number of lesions increased in 2, was stable in 1, decreased in 3, and disappeared in 1. The imaging and clinical characteristics suggested a foreign body reaction. We could find no correlation to a specific device, but a possible source may be the generic hydrophilic coating. ABBREVIATION: EVT ϭ endovascular therapy

No abstract

We analyze the future state of Quelccaya Ice Cap (QIC), the world’s largest tropical ice cap with a summit elevation of 5680 m a.s.l., which, in terms of its elevation range (~5300–5680 m a.s.l.), is representative of many low-elevation glacierized sites in the tropical Andes. CMIP5 model projections of air temperature (Ta) at QIC indicate a warming of about 2.4 °C and 5.4 °C (respectively) for RCP4.5 and RCP8.5 scenarios by the end of the 21st century, resulting in a pronounced increase in freezing level height (FLH). The impact of this warming on the QIC was quantified using equilibrium-line altitude (ELA) projections. The change in the ELA was quantified based on an empirical ELA–FLH relationship, and calibrated with observations of the highest annual snowline altitude (SLA) derived from LANDSAT data. Results show that from the mid-2050s onwards, the ELA will be located above the QIC summit in the RCP8.5 scenario. At that time, surface mass balance at QIC and most tropical glaciers at similar elevations will become increasingly negative, leading to their eventual complete disappearance. Our analysis further corroborates that elevation-dependent warming (EDW) contributes significantly to the enhanced warming over the QIC, and that EDW at Quelccaya depends on the rate of anthropogenic forcing.