No abstract

SummaryThe capacity of brain and peripheral organs to accumulate dopamine following intraperitoneal 1-dopa was not impaired in rats whose catecholamine-containing nerve terminals had been destroyed by pretreatment with intracisternal or intraperitoneal 6-hydroxydopamine. These findings indicate that the uptake of exogenous 1-dopa and its conversion to dopamine are not restricted to cells that normally synthesize and contain catecholamines.

No abstract

No abstract

No abstract

RESUMENEn la primavera de 1995 se produjo el descubrimiento de la Cueva del Moro con un conjunto de figuraciones grabadas de équidos con. una filiación superopaleolítica indudable. Los numerosos hallazgos que se están produciendo desde hace unos años en la zona del Campo de Gibraltar nos indican que se trata de una área con una (*) Codirectores

-

The reference diagnostic test of fibrosis, steatosis, and hepatic iron overload is liver biopsy, a clear invasive procedure. The main objective of this work was to propose HSA, or human serum albumin, as a biomarker for the assessment of fibrosis and to study non-invasive biomarkers for the assessment of steatosis and hepatic iron overload by means of an MR image acquisition protocol. It was performed on a set of eight subjects to determine fibrosis, steatosis, and hepatic iron overload with four different MRI sequences. We calibrated longitudinal relaxation times (T1 [ms]) with seven human serum albumin (HSA [%]) phantoms, and we studied the relationship between them as this protein is synthesized by the liver, and its concentration decreases in advanced fibrosis. Steatosis was calculated by means of the fat fraction (FF [%]) between fat and water liver signals in “fat-only images” (the subtraction of in-phase [IP] images and out-of-phase [OOP] images) and in “water-only images” (the addition of IP and OOP images). Liver iron concentration (LIC [µmol/g]) was obtained by the transverse relaxation time (T2* [ms]) using Gandon’s method with multiple echo times (TE) in T2-weighted IP and OOP images. The preliminary results showed that there is an inverse relationship (r = −0.9662) between the T1 relaxation times (ms) and HSA concentrations (%). Steatosis was determined with FF > 6.4% and when the liver signal was greater than the paravertebral muscles signal, and thus, the liver appeared hyperintense in fat-only images. Hepatic iron overload was detected with LIC > 36 µmol/g, and in these cases, the liver signal was smaller than the paravertebral muscles signal, and thus, the liver behaved as hypointense in IP images.