The dose used herein was found to inhibit bone loss and to cause marked morphologic changes in osteoclasts. The drug effectively prevented bone loss caused by periodontitis.

Several studies have confirmed a decrease in the quality and quantity of milk of mothers with diabetes during lactation. However, it remains unclear how maternal diabetes affects the offspring specifically during lactation. The aim of this study was to evaluate body and mandibular growth and tooth eruption in pups suckling from diabetic dams. The study was performed on 13 Wistar rat pups that were born to dams that were subjected to experimental diabetes on the day of parturition. Body weight and body size were recorded regularly throughout the study. The experimental pups and a group of eight age-matched pups suckling from nondiabetic dams were killed at weaning. Both hemimandibles were excised and fixed. Right hemimandibles were radiographed to assess mandibular growth and tooth eruption. The left hemimandibles were processed to obtain buccolingually oriented sections at the level of the first mesial root of the first lower molar. Histologic and histomorphometric studies were performed. Results showed that body weight and body size were significantly lower in experimental animals at weaning compared with their age-matched controls. Smaller mandible size and reduced tooth eruption in experimental animals compared with controls were observed. The length, width, and bone volume of the developing alveolus were reduced in experimental animals compared with controls. The results obtained in this study allow the conclusion that suckling from diabetic dams results in reduced body, mandible size, and tooth eruption of the pups at weaning. Diabetes encompasses a group of metabolic diseases characterized by hyperglycemia, which results from decreased insulin secretion, from functional deficiency of insulin action, or both. Diabetes-associated chronic hyperglycemia causes dysfunction, long-term damage, and failure of several body organs (1).When a mother has diabetes, the alterations in maternal metabolism cause damage to the offspring, not only during gestation but also during lactation. Alterations in maternal metabolism during gestation are responsible for fetal macrosomia and congenital malformations, among other consequences (2,3). There are reports of the long-term effects of neonatal breastfeeding in children of mothers with pregestational diabetes during pregnancy (4). It may result in an increased risk for becoming overweight and developing impaired glucose tolerance during childhood. Moreover, diabetic dams have decreased yield and altered composition of the milk (5-9). Alterations in maternal metabolism caused by diabetes during lactation may affect the offspring specifically when the known effects that maternal diabetes has on their pups during pregnancy are excluded. Thus, the first aim of this study was to measure the effect of reduced milk quality and quantity on body size and weight of the pups of dams that were rendered diabetic before lactation.Tooth eruption is a complex process in developmental biology and is yet to be fully understood. Tooth and periodontal development are two major events associated ...

No abstract