#6078 Background: Fibroadenoma is the commonest benign tumor of female breast, classified as fibroepithelial neoplasia. It is frequent during reproductive years mainly in the 2nd and 3rd decades of life, coinciding with follicular maturation and steroidogenesis. With the beginning of the era of transplants the use of cyclosporine A was accepted by the medical community as potential lymphocyte T suppressant. In 1980 the first report on multiple breast fibroadenomas in renal transplant patients taking cyclosporine A was published. The imaging standard of fibroadenomas also seems to differ from usually found in asymptomatic patients: diameters are notably larger, lower longitudinal / anteroposterior diameter ratio and are more hyperechogenic.
 Objetive: To define the prevalence of breast fibroadenomas in kidney-transplanted patients taking cyclosporine A.
 Materials and Methods: Prevalence of breast fibroadenomas was determined in three groups of patients: 50 women with renal transplant taking cyclosporine A (Group 1); 51 women with renal transplant not taking cyclosporine A (Group 2) and 181 women without renal transplant (Control Group). Evaluation was performed by anamnesis, physical examination and breast ultrasonography. In the case of clinical or imaging suspicion of fibroadenoma, the diagnosis was confirmed by core needle biopsy or lumpectomy.
 Results: The groups were homogeneous regarding age, menstrual status and former breast cancer family history. Fourteen percent fibroadenomas were found in the renal transplant patient group taking cyclosporine A versus 2.0% in the renal transplant patient group not taking cyclosporine A, and 2.8% in the control group. Prevalence of breast fibroadenomas in renal transplant patients taking cyclosporine A was significantly higher than in those not taking the drug and than in the control group (p=0.001). Frequency of fibroadenomas of the control group and renal transplant patients not taking cyclosporine was similar (p=0.073). Multiplicity, bilaterality and greater nodule dimensions were observed more in renal transplant patients taking cyclosporine A, but there was no statistical significance among the groups.
 
 Conclusion: Breast fibroadenomas are more prevalent in the renal transplant patients taking cyclosporine A. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6078.
#2038 Background: The immune response initiation requests the capture and the presentation of the antigens to the specific lymphocytes. The cells that has this capacity are denominated antigen-presenting cells, and the dendritic cell (DC) is the one that has larger specialization degree for these functions. The DC maturation it is considered essential for the beginning of the immune response. The CD83 antigen is a co-stimulator, member of the immunoglobulin superfamily with 45Kd, and your expression is an important marker of the maturation of DC.
 Objectives: To analyze the CD83 antigen expression in the human's breast fibroadenoma and in the adjacent breast tissue and to identify the clinical features that can influence this expression.
 Material and Methods: It is a retrospective study where 29 histopathologic materials of breast fibroadenomas and the adjacent breast tissue, of 28 women in reproductive age, were analyzed. The immunohistochemistry method was used for analysis of the CD83 antigen expression and, subsequently, the cells were counted by light microscopy. A thousand epithelium cells of each case were analyzed (five hundred of the fibroadenoma and five hundred of the adjacent breast tissue) for statistical calculation of the expression or not of the antigen reaction in the cells. We used parametric test (t-Student) for statistical analysis of the results.
 Results: The CD83 antigen expression positive in the fibroadenoma's cells (365.52 ± 133.13) in relation to the adjacent breast tissue's cells (189.59 ± 140.75) was statistically greater (p <0.001). Several clinical features were analyzed, however, only parity showed influence in the expression of the CD83 antigen in the adjacent mammary tissues, and the positive expression was more evident in nulliparous women (p=0.042).
 
 Conclusion: The CD83 antigen expression was statistically greater in the breast fibroadenoma's cells, when compared with the one of the adjacent breast tissue. No clinical variable influenced CD83 expression in the breast's fibroadenoma, however, it was significantly greater in the adjacent normal breast tissue of nulliparous women. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2038.
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