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Darier's disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier's disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier's disease occurred in this patient. Paraneoplastic Darier's disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here.

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA). It is characterized by a progressive peripheral expansion and central healing leaving atrophic scar. It is sometimes confused with squamous cell carcinoma (SCC) both clinically and histopathologically. We here report a case of KCM over the extensor aspect of the right forearm in a 57-year-old man with an abnormal looking scar.

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Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. The incidence of BCC is rising. The nodular, superficial spreading, and infiltrating variants are the three most commonly encountered types of BCC in descending order of prevalence. Superficial spreading basal cell carcinoma (SSBCC) accounts for 15-26% of all cases of BCC. It usually occurs on the trunk and upper extremities, but may be seen on the face. Surgical excision is the most commonly used treatment for BCC. Topical chemotherapy agents such as imiquimod or 5-fluorouracil (5-FU) may be various alternatives or adjuvants in the treatment of SSBCC. characteristically shows areas of uninvolved skin between tumor nests.[7]

The optimization of ajoene and 2-vinyl-4H-1,3, dithiin during the garlic mustard oil macerate (GMM) preparation was carried out using response surface methodology. The independent variables were time of heating, temperature of heating and amount of mustard oil. The optimum preparation condition for ajoene was a temperature of 55 oC, a reaction time of 4.5 hours, and an oil volume of 2.00 factor of weight of garlic; and for 2-vinyl-4H-1,3, dithiin, the conditions were a temperature of 77.51 oC, a reaction time of 2.22 hours and oil volume of 2.25 factor of weight of garlic. The predicted value of ajoene and 2-vinyl-4H-1,3, dithiin were 2387.24 µg/ml of GMM and 4806.11 µg/ml of GMM respectively. The experimental values were found to be 2186.58 µg/ml of GMM and 4363.27 µg/ml of GMM for ajoene and 2-vinyl-4H-1,3, dithiin respectively.

Curcumin (CurH3) forms a blue derivative (CurH2−) when it combines with superoxide radicals. The blue colouring is caused by the proton loss of curcumin to the superoxide radicals. In DMSO, in the presence of excess NaOH and dissolved oxygen, superoxide radicals are produced by consuming the hydroxyl ion which causes the deprotonation of curcumin (Cur3−) and gives the corresponding orange colour. The production of superoxide radicals increased as it was more exposed to air (maybe oxygen). As a result, the pH drops, and the orange derivative is protonated by one H+ ion, producing the corresponding blue colour derivative (CurH2−). The conversion of the orange derivate to the blue derivative may suggest the presence of oxygen in the surrounding atmosphere, allowing the feasibility of a novel oxygen sensor. The physicochemical characteristics and stability of this blue-coloured curcumin derivative are investigated. The distinct colour shifts of curcumin upon the addition of different volumes of NaOH were also investigated. The UV-Vis and FTIR analyses were used to study the stability of the blue curcumin derivative.