We present updated orbital elements for the Wolf–Rayet (WR) binary WR 140 (HD 193793; WC7pd + O5.5fc). The new orbital elements were derived using previously published measurements along with 160 new radial velocity measurements across the 2016 periastron passage of WR 140. Additionally, four new measurements of the orbital astrometry were collected with the CHARA Array. With these measurements, we derive stellar masses of $M_{\rm WR} = 10.31\pm 0.45 \, \mathrm{M}_\odot$ and $M_{\rm O} = 29.27\pm 1.14 \, \mathrm{M}_{\odot }$. We also include a discussion of the evolutionary history of this system from the Binary Population and Spectral Synthesis model grid to show that this WR star likely formed primarily through mass-loss in the stellar winds, with only a moderate amount of mass lost or transferred through binary interactions.
A series of compounds with different R groups, such as aliphatic and aromatic amides, carbamates, sulfonamides, and ureas, has been tested and all of the compounds showed very similar affinities to E-selectin. Compounds 3 b ± d were selected as representative examples. See: R.[20] NMR spectroscopic measurements were carried out on a Varian UnityPlus 600 spectrometer operating at a frequency of 600 MHz. All experiments were carried out at 25 8C with compound concentrations of approximately 10 mm in D 2 O solutions. ROESY experiments were carried out with mixing times of 150 ms. For some compounds, ROESY spectra were recorded using 50 ms and 100 ms mixing times, and the results were indistinguishable. Typical acquisition times in the direct and indirect dimensions were 340 ms and 64 ms, respectively. The data were zero-filled to yield a digital resolution of 1.46 Hz and 2.92 Hz, respectively. For bound 2, NOE values were extracted from transfer NOE spectra (see ref.[7b]). Signal integration was performed using Varian VNMR software. All NOEs were normalized using intraglycosidic NOE enhancements such as H1 G ± H3 G and H4 F ± H5 F . The distances between these hydrogens are given by the chair conformations of fucose and galactose and should be very similar for compounds 2, 4, 5, and 6. It should be noted that the measured NOE values do not refer to a distinct conformation of the molecule but represent the weighted mean distance over several coexisting low energy conformations.[21] a)
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