S U M M A R Y1. We have used the rebreathing method to examine the respiratory response to CO, in five normal subjects and twelve patients with diffuse pulmonary infiltration or fibrosis. The response to CO, was measured in terms of both ventilation and mechanical work rate.2. The response to CO, was, on average, reduced in the patients compared with the normals but the patients had to perform more mechanical work to achieve a given level of ventilation.3. Six patients had an abnormally low resting mixed venous Pco, and four of these also had an abnormally low response to CO,.4. The pattern of breathing was identical in patients and normals. 5. The results indicate that the reduced ventilatory response represents a true loss of CO, sensitivity and is not simply due to mechanical limitation; but the paradox in some patients of resting hyperventilation and a low level of CO, responsiveness is unexplained.
till the last child was born, since which time she has occasionally missed one or two periods, which she thought was due to a change of life. History of Pregnancy.\p=m-\June29, 1904, she commenced vomiting, and a few days later menstruation failed to appear. July 1, 1904, her husband, whose work called him to Idaho, left here, and did not return till sometime after the confinement. When he left both patient and husband considered that she was pregnant. During the entire pregnancy she lived here with her seven children. The last menstruation
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