The Ventilatory Response to CO2 of Patients with Diffuse Pulmonary Infiltrations or Fibrosis

Patton, Joseph M.; Freedman, Steven J.

doi:10.1042/cs0430055

Cited by 11 publications

(4 citation statements)

References 17 publications

(20 reference statements)

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“…Patients with IPF are tachypneic; they develop more rapid shallow breaths as the disease progresses, and therefore the work of breathing is increased (123,124). This rapid respiratory rate is felt to be secondary to altered mechanical reflexes, because of the increased elastic load and/or vagal mechanisms, since no defined chemical basis for the hyperventilation has been identified (125)(126)(127)(128)(129)(130)(131)(132). Expiratory flow rates, forced expiratory volume in 1 s (FEV,), and forced vital capacity (FVC) are often decreased because of the reduction in lung volume, but the FEV,-to-FVC ratio is maintained or increased in IPF.…”

Section: Pulmonary Function Testingmentioning

confidence: 99%

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000

Am J Respir Crit Care Med

2,314

497

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Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases. Idiopathic pulmonary fibrosis (or cryptogenic fibrosing alveolitis) (IPF or CFA) is one of several idiopathic interstitial pneumonias. IPF is now recognized as a distinct clinical disorder. Despite major accomplishments in our understanding of the pathogenesis of lung fibrosis (l), the diagnosis and management of patients with IPF continues to pose significant challenges (24). OBJECTIVE This is an international consensus statement defining the diagnosis, evaluation, and management of patients with IPF that has been produced as a collaborative effort from the American Thoracic Society (ATS), European Respiratory Society (ERS), and the American College of Chest Physicians (ACCP). The purpose of this consensus statement is to provide assistance to clinicians in the diagnosis and management of idiopathic pulmonary fibrosis (IPF). The targeted providers are pulmonary subspecialists. PARTICIPANTS Panel members are experts in adult pulmonary diseases. Panel members were nominated by the supporting associations. The chair was selected by the American Thoracic Society. Panel members were selected because of an interest and expertise in the interstitial lung disease and to provide a range of opinions, expertise, and geography. EVIDENCE The expert panel was provided with background articles that reviewed the existing scientific evidence. Relevant articles from the medical literature were identified by a MedLine search (1966 to December 1998) of English language articles or articles with English abstracts, the bibliographies of the articles retrieved, and the authors' files. In addition, articles in other languages were also obtained from the bibliographies of the articles retrieved and were reviewed or translated by pulmonary physicians knowledgeable in this area. All articles in which IPF was identified were included in this review. More than 3,500 published reports were critically reviewed for information on IPF, including its physiologic, radiologic, and pathological findings; its pathogenesis, epidemiology, clinical presentation, and staging; its inheritance or familial occurrence; its treatment (including lung transplant); and its prognosis. The panel was divided into subgroups responsible for the re

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Section: Pulmonary Function Testingmentioning

confidence: 99%

Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment

2000

Am J Respir Crit Care Med

2,314

497

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“…It has been suggested that the C 0 2 response of an individual is related to the ability to perform increased pulmonary work (5,10). The data obtained in this study of premature infants suggest that the infants who appear to be unresponsive to C 0 2 are either ( 1 ) performing respiratory work at the maximum rate possible or (2) truly lack reflexes for C 0 2 sensitivity.…”

Section: Discussionmentioning

confidence: 67%

Ventilatory Response to Carbon Dioxide in Newborn Infants

et al. 1975

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ExtractIn order to determine whether the mechanical characteristics of the lungs of newborn infants imposed limitations on their ventilatory response to carbon diozide, I I premature and 5 full term infants ranging in gestational ages from 28-40 weeks and in birth weights from 964 to 4,040 g were studied by a rebreathing technique. Sensitivity to carbon dioxide determined by this method revealed a good correlation with compliance (r = 0.6, P < 0.001), and an even stronger correlation with gestational age (r = 0.84, P < 0.001). Because compliance also improved with increasing postconceptional age, the current study does not permit one to differentiate between neurologic or pulmonary mechanical factors which may affect ventilatory response to carbon dioxide. Speculation

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“…A significant finding was the failure of some infants to increase either tidal volume or respiratory rate during COz rebreathing. It has been suggested that the C 0 2 response of an individual is related to the ability to perform increased pulmonary work (5,10). The data obtained in this study of premature infants suggest that the infants who appear to be unresponsive to C 0 2 are either ( 1 ) performing respiratory work at the maximum rate possible or (2) truly lack reflexes for C 0 2 sensitivity.…”

Section: Discussionmentioning

confidence: 67%