ABSTRACT.Purpose: Corneal hysteresis (CH) is lower in glaucomatous eyes. The aim of this study was to determine and compare the change in CH over time between normal, open angle glaucoma (POAG) and diabetic subjects. Methods: We retrospectively analysed records of patients undergoing assessment with the Ocular Response Analyzer (Reichert, Corp., New York, NY, USA). Right eyes with at least 7 measurements were included. Patients with ocular pathology other than POAG were excluded. Two-sample t-tests, chisquared and logistic regression were used to analyse data. Results: A total of 1418 normal and 322 POAG patients were included. Patients with POAG were significantly older (70.73 AE 11.33 vs. 61.59 AE 16.56 years; p < 0.001), had a longer follow-up (4.14 AE 1.34 vs. 2.72 AE 1.49 years; p < 0.001) and had lower CH (9.58 AE 2.17 vs. 9.95 AE 2.19 mmHg p = 0.01), but there were no gender differences between groups (61.5 vs. 57.7% female; p = 0.21). We observed a significantly greater decrease in CH among patients with POAG (À0.11 AE 0.73 vs. 0.07 AE 2.31 mm Hg/year; p = 0.02). The relation between ΔCH/year and diagnosis persisted after adjusting for age and follow-up time (OR 0.90; 95% CI 0.82, 0.99; p = 0.03). We found CH to be higher in diabetics vs. non-diabetics (10.34 AE 2.04 vs. 9.88 AE 2.19; p = 0.02), but ΔCH/year was not different (0.07 AE 1.27 vs. 0.03 AE 2.10; p = 0.77). Conclusions: Patients with POAG in this study had a significantly greater rate of CH decline compared to normal. There was no significant difference in rate of CH change in diabetic and non-diabetic patients.
Purpose: To report a case of pattern dystrophy in a patient with McArdle disease, a rare autosomal recessive disorder of glycogen metabolism.Methods: Case report.Results: A 29-year-old woman with a history of muscle biopsy-confirmed McArdle disease presented with fundus findings consistent with pattern dystrophy. Multimodal imaging, including optical coherence tomography and fundus autofluorescence, was performed.Conclusion: To our knowledge, this is the third reported case of pattern dystrophy in a patient with McArdle disease.
A case of Vogt–Koyanagi–Harada-like uveitis followed by melanoma-associated retinopathy with focal chorioretinal atrophy and choroidal neovascularization in a patient with metastatic cutaneous melanoma
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