The acute contra-inflammatory effects of salicylic acid, three standard dermatocorticoids and four contact antiphlogistics have been investigated by means of a UV dermatitis inhibition test in the guinea pig. The substances tested had a distinct inhibitory effect on the development of erythema and can be ranked in the following ascending order of activity (percent of maximum possible score): bufexamac = 36%, salicylic acid = 37%, hydrocortisone = 44%, acetylsalicylic acid = 48%, flumethasone pivalate = 51%, fluocinolone acetonide = 52%, phenylbutazone = 56%, and indomethacin = 58%.
Assays of steroidal and non-steroidal drugs in an experimental model of dermatitis induced in the ear of the rabbit by the application of a solution of croton oil revealed clearly differentiable inhibitory effects on the rise in skin temperature, the oedema and the increase in tissue mass due to the inflammatory process. The results obtained in this test system fairly accurately reflect the relative therapeutic potencies of known dermatocorticoids and, in conjunction with those found by other methods, afford a more exact characterization of the activity profiles of non-steroidal contra-inflammatory agents.
The auricle of the rabbit ear appears particularly well suited as a histometrically evaluable model for assessing the reactions of the sebaceous glands to topical and systemic influences. Treatment of juvenile castrate rabbits with eight doses of 100 mg of a depot androgen (Triolandren®) over a period of 4 weeks led to a pronounced hyperplasia of the auricular glands: their average sectional area increased by 127% in relation to the initial values, whereas untreated control animals showed an increase of only 39% within the same period.
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