O transtorno da ansiedade é uma das condições neuropsiquiátricas mais prevalentes com cerca de 264 milhões de pessoas no mundo vivem com estes distúrbios. Ela é desencadeada quando um indivíduo confrontado com uma dada situação ou evento não é capaz de responder as demandas e sente uma ameaça à sua existência ou valores essenciais. Esse transtorno possui uma multifatorialidade em sua etiologia, dando ênfase sobretudo nos fatores genéticos, ambientais e neurobiológicos. Os principais agentes medicamentosos mais utilizados são os benzodiazepínicos e os não benzodiazepínicos, no entanto o uso e a recomendação destes agentes é limitada. Este estudo se classifica em uma revisão narrativa de cunho qualitativo. Além disso, o tratamento medicamentoso dos sintomas por completo ainda permanece desconhecida. Assim, esta revisão possui o intuito de discutir as principais bases fisiológicas desse transtorno, bem como o tratamento e seus efeitos.
Obesity, metabolic syndrome and diabetes are epidemic chronic situations in industrialized countries that are associated with the reduction of life quality and increase of patients’ mortality. Before the serious epidemiological picture and the impact that the diabetes causes in the society, the use of different therapeutic interventions is priority in the scientific community. Thus, the goal of this work valued the hypoglycemic effect of the aqueous and methanolic extracts of the leaves of Cnidoscolus quercifolius Pohl (faveleira). The phytochemical analysis demonstrated the carbolic acids presence, flavonols, xanthone, catechin, triterpenoids, tannin and coumarins in both extracts and the liquid chromatography of high efficiency revealed the presence of the gallic acid; a powerful metabolite antioxidant. The Diabetes was induced in mice Swiss with alloxan that they did not present mortality when treated with 100, 200 mg / kg of methanolic extract and 100, 200 and 400 mg / kg of aqueous extract for 30 days. Histopathological analysis of the animal’s organs (kidney, pancreas, liver) did not reveal architectural alteration. All the diabetic animals submmited to the extracts presented a higher reduction on the blood sugar level percentage than the ones which were undergone to the standard drug. It is important to highlight that the blood sugar level - of the diabetic animals undergone to 400 mg / kg of weight of the aqueous extract - presented glycemic reduction of 39,81 % after 30 days of treatment. These results are very promising because they show great potential for the use of this typical Brazilian Caatinga plant as an alternative therapeutic option to slow down or reduce the risk of hyperglycemia and oxidative stress in diabetic patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.