Hypolipidemic and reduced nitrergic effects of p-hydroxycinnamic diesters extracted from Copernicia prunifera in mice challenged by a high-fat diet

Silva, José Ytalo Gomes da; Rodrigues, Paula Alves Salmito; Holanda, Marcelo Oliveira; Silva, Bruno Bezerra da; Lima, Carla Laíne Silva; Lira, Sandra Machado; Moura, Luiz Francisco Wemmenson Gonçalves; Paim, Raquel Teixeira Terceiro; Florean, Eridan Orlando Pereira Tramontina; Marques, Márcia Maria Mendes; Oriá, Reinaldo B.; Mendes, Francisca Noélia Pereira; Vieira, Ícaro Gusmão Pinto; Guedes, Maria Izabel Florindo

doi:10.1016/j.biopha.2021.111930

Cited by 4 publications

(8 citation statements)

References 37 publications

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“…According to numerous reports, these compounds have strong hypolipidemic potential. 49 , 50 Furthermore, other Teucrium species have been reported to exhibit antihyperlipidemic effects. For example, a hydroalcoholic extract of T. polium from Iran was tested on dexamethasone-induced hyperlipidemic rats.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical analysis, antioxidant, and antihyperlipidemic activities of Teucrium takoumitense

El-Guourrami,

Elbouny,

Ait Benlabchir

et al. 2023

Journal of Taibah University Medical Sciences

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Section: Discussionmentioning

confidence: 99%

Phytochemical analysis, antioxidant, and antihyperlipidemic activities of Teucrium takoumitense

El-Guourrami,

Elbouny,

Ait Benlabchir

et al. 2023

Journal of Taibah University Medical Sciences

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“…This effect was most significant in ‘Sandon Rose’ cultivar. Several authors have shown that the intake of these compounds have a positive effect on consumers' health due to their cardio‐preventive effects and their ability to regulate cholesterol metabolism 33‐35 . However, anthocyanins are responsible for the antioxidant activity of cherries, which varies depending on the cultivar studied 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Several authors have shown that the intake of these compounds have a positive effect on consumers' health due to their cardio-preventive effects and their ability to regulate cholesterol metabolism. [33][34][35] However, anthocyanins are responsible for the antioxidant activity of cherries, which varies depending on the cultivar studied. 36 However, a previous study 37 concluded that antioxidant activity is not only related to these compounds.…”

Section: Discussionmentioning

confidence: 99%

Effect of preharvest melatonin applications at dusk on quality and bioactive compounds content of early sweet cherries

Cortés‐Montaña,

Bernalte‐García,

Palomino‐Vasco

et al. 2023

J Sci Food Agric

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BACKGROUNDEarly sweet cherries have a high economic impact on cherry growers but have poorer quality characteristics and shorter shelf‐life than late cherries. Melatonin has been proposed as a biostimulant that regulates plant and fruit growth and increases fruit quality and shelf‐life but, in general in fruit and vegetables, there is controversy about its effects. Therefore, this work aimed to evaluate the impact of exogenous preharvest melatonin applications at dusk on the quality and bioactive compounds of two early sweet cherry cultivars.RESULTSM3 and M5 (3·10‐4 and 5·10‐4 M melatonin, respectively) treatments effectively enhanced the endogenous melatonin and hydroxycinnamic acid concentration, enhancing the functional properties of the fruit. Additionally, the M5 treatment enhanced skin colour and consumer acceptance of 'Samba', while the M3 treatment improved cherry size in 'Sandon Rose'.CONCLUSIONPreharvest melatonin applications at dusk could be included in the scheduled preharvest treatments for early cherry cultivars in order to improve the quality and to stimulate the functionality of the fruit. However, further studies are needed to adjust the concentration depending on the cultivar and the objective pursued.This article is protected by copyright. All rights reserved.

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“…Animals were randomly subdivided into two groups. The rst group of mice daily received vehicle (dimethyl sulfoxide -DMSO 0.03%, Cat# 276855 Merk) dissolved in water by gavage to serve as the control group; the second group received a daily oral dosage of simvastatin 20 mg kg − 1 (Cat# S6196 Merk) following published procedures 23 . Each experimental group included ve mice.…”

Section: Methodsmentioning

confidence: 99%

“…Next, we moved on to exploring whether simvastatin could cause changes in ECS activity in vivo. For this purpose, 10-week-old male C57BL/6J mice were randomized into two groups receiving a daily oral dose of simvastatin 20 mg kg − 1 by gavage for 30 days following published protocol 23 . Following this procedure, we found that, in mice treated with simvastatin, muscle strength was signi cantly reduced compared to their control littermates (Figure S3), con rming a plausible increased statin-dependent susceptibility to myopathy.…”

Section: Simvastatin Causes Alterations Of Ecs Signaling In the Skele...mentioning

confidence: 99%

MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity

Kalkan

Panza

Pagano³

et al. 2022

Preprint

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Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in 1 in 10.000 patients. In this study, we explored the role of the endocannabinoid system (ECS) during muscle toxicity induced by simvastatin. In murine C2C12 myoblasts exposed to simvastatin (30 µM), we found that the levels of the endocannabinoids 2-AG and AEA as well the expression of specific miRNAs (mostly miR-152) targeting the endocannabinoid CB1 gene were increased. Rimonabant, a selective CB1 antagonist, exacerbated simvastatin-induced toxicity in myoblasts, while the opposite effect was observed with GAT211, a CB1-positive allosteric modulator. In antagomiR-152-transfected myoblasts, simvastatin toxicity was prevented along with the rescue of CB1 expression. Notably, similar alterations were found in skeletal muscles of C57BL/6J mice treated with simvastatin 20 mg Kg-1 and in primary human myoblasts. In sum, we identified the ECS as a novel mechanism participating in statin-induced myopathy.

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Hypolipidemic and reduced nitrergic effects of p-hydroxycinnamic diesters extracted from Copernicia prunifera in mice challenged by a high-fat diet

Cited by 4 publications

References 37 publications

Phytochemical analysis, antioxidant, and antihyperlipidemic activities of Teucrium takoumitense

Phytochemical analysis, antioxidant, and antihyperlipidemic activities of Teucrium takoumitense

Effect of preharvest melatonin applications at dusk on quality and bioactive compounds content of early sweet cherries

MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity

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