CASE REPORTA 39-year old Caucasian male presented with a 15-year history of asymptomatic lesions on his penis. Physical examination revealed linear lesions with fine keratotic walls and an atrophic, violaceous center on the dorsum of the penis (Figure 1). No other lesions were identified on any area of his body. There was no family history of any similar skin disorders and the patient was not on any drugs. Histopathological examination showed findings consistent with porokerato-
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WHAT IS YOUR DIAGNOSIS?FIGURE 1: Linear lesions with fine keratotic walls and atrophic, violaceous center on the dorsal shaft of the penis FIGURE 2: Cornoid lamella and underlying diskeratosis (HE, 200x) sis: hyperkeratotic and parakeratotic stratum corneum (cornoid lamella) and underlying diskeratosis ( Figure 2). The patient was treated with topical liquid-nitrogen cryotherapy for five sessions over a 6-month period. Over the 2-year follow-up period, the lesion improved and there is no evidence of recurrence or malignant transformation. The patient's informed consent was obtained for this report.
Beginning the study of chronic pathologic changes in pancreas of hamsters experimentally infected with Trypanosoma cruzi Vic strain, hepatocyte metaplasia was observed in one animal from infected group. This is the first report of oncocytes in Chagas' disease, which could be due to aberrant regenerative response to pancreas inflammatory process.
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