Case for diagnosis

Gonçalves, Sheila Viana Castelo Branco; Valente, Neusa Yuriko Sakai; Junior, José Vitor de Oliveira; Paiva, Daniele Loureiro Mangueira

doi:10.1590/s0365-05962012000300026

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…A therapeutic success was achieved using diamond fraise dermabrasion in one patient, with partial repigmentation and no recurrence [414]. As in the other forms of porokeratosis, LP can also be managed using cryotherapy [415,416], yet some cases tend to be unresponsive to this treatment [417].…”

Section: Treatmentmentioning

confidence: 96%

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Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Section: Treatmentmentioning

confidence: 96%

“…Cryotherapy completely cleared the lesions in four VP cases [345,416,511,512], demonstrated some/temporal effectiveness in four cases [191,290,465,471] and a poor outcome in three cases [465,507,513]. Considering the treated site, the main limitation for the procedure was pain [471].…”

Section: Treatmentmentioning

confidence: 96%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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“…A similar case was reported in a 39-year-old male, which resolved by liquid nitrogen cryotherapy over a 6-month period and without recurrence at 2 years. 19 …”

Section: Genitogluteal Porokeratosismentioning

confidence: 99%

Genitogluteal porokeratosis: a clinical review

Joshi¹,

Minni²

2018

CCID

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Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life. Genitogluteal porokeratosis is usually pruritic and may be undiagnosed for several years as it does not resemble classical porokeratosis in many cases; however, a biopsy is diagnostic. In general, response of genital porokeratosis to any modality of treatment is disappointing. No malignant changes have hereto been reported in porokeratosis restricted to the genitogluteal region.

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