Indeterminate lung nodules (LN) constitute a clinical problem of increasing frequency that requires an effective diagnostic approach. This study evaluates the contribution of 99mTc-depreotide scintigraphy in the management of such patients. Forty (40) patients (27 males/13 females) 29 to 82 years old (61 +/- 12) with lung nodules/masses of indeterminate origin on computed tomography (CT) images were injected with 99mTc-depreotide and underwent thoracic tomography (single photon emission computed tomography) 2 and 4-4.5 hours later. All parenchymal lesions (50) identified by CT were scored as negative or positive as to the uptake of 99mTc-depreotide. Positive images were also evaluated semiquantitatively. Thirty (30) of 31 malignant lesions were positive (97% sensitivity) and 12 out of 19 benign lesions were negative (63% specificity), with positive images obtained in benign processes such as inflammation/infection and bronchiectasis. Semiquantitative analysis showed a statistically significant difference between benign and malignant positive lesions on the late images, and may play a complementary role in interpretation. 99mTc-depreotide was a useful noninvasive tool in the evaluation of patients with LN, allowing for the exclusion of malignancy with great confidence, due to its high sensitivity. Because of moderate specificity, a positive test is best valued together with clinical and radiological features.
Carcinoma adenóide quístico recorrente. Revisão a propósito de um caso clínico Recurrent adenoid cystic carcinoma. Review based on a case report Recebido para publicação/received for publication: 08.07.15 Aceite para publicação/accepted for publication: 08.09.11
Sclerosing hemangioma of the lung is an uncommon benign tumour which usually presents as an asymptomatic solitary nodule. Multiplicity is very rare. The authors describe a case of a 50 year-old asymptomatic woman with multiple nodular lesions involving all the lobes of both lungs, which underwent diagnostic thoracotomy after thorough investigation to exclude extra-pulmonary neoplasia. The biopsies obtained led to the diagnosis of pulmonary sclerosing hemangiomas. This is one of the few cases described with this presentation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.