Aqueous and solid magnetoliposomes containing MnFe2O4 nanoparticles were prepared and evaluated as nanocarriers for a new antitumor drug.

The fluorescence properties of the new potent antitumoral methyl 3-amino-6-(benzo[d]thiazol-2-ylamino)thieno[3,2-b]pyridine-2-carboxylate in solution and when encapsulated in several different nanoliposome formulations were investigated. The compound exhibits very reasonable fluorescence quantum yields and a solvent sensitive emission in several polar and non-polar media, despite not being fluorescent in protic solvents. Fluorescence anisotropy measurements of the compound incorporated into liposomes revealed that this thienopyridine derivative can be carried in the hydrophobic region of the lipid membrane. Liposome formulations including this antitumor compound are nanometric in size, with a diameter lower than 130 nm and generally low polydispersity, and are promising for future drug delivery developments. The interaction of the compound with bovine serum albumin (BSA) and the multidrug resistance protein MDR1 was monitored by FRET, the compound acting as an energy acceptor. It was observed that the drug had a lower interaction with the MDR1 protein than with the native form of BSA, which is an important result regarding applications of this antitumoral drug.

International audienceDiffusion coupling in multiply associating aqueous electrolyte solution is studied. The process is illustrated in the case of zinc(II) ion which forms a set of complexes, ZnCl 2−n n (with n = 1, .., 4), in the presence of chloride ions. The transport of zinc ion, taken in radioactive form 65 Zn 2+ , in the electric field created by a gradient of LiCl, is investigated experimentally by employing an adaptation of the closed capillary technique. The transient diffusion process is modeled by using two different treatments: finite difference (FD) simulation and normal mode (NM) analytic solution. Deviations from ideality are taken into account with the use of the mean spherical approximation (MSA), and the internal electric field is calculated using the dynamical electroneu-trality condition. The theoretical FD and NM results are compared with the experimental data about the diffusion of zinc

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