Magnetoliposomes based on manganese ferrite nanoparticles as nanocarriers for antitumor drugs

Abstract

Aqueous and solid magnetoliposomes containing MnFe2O4 nanoparticles were prepared and evaluated as nanocarriers for a new antitumor drug.

Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

“…Our results in Figure S4 confirm that fusion with GUVs occurs for both AMLs of Egg-PC and DPPC. This result is similar to those previously observed with aqueous magnetoliposomes of Egg-PC containing different types of magnetic nanoparticles [25,26,60].…”

“…A hydrodynamic diameter of 112±19 nm was determined ( Figure S3 in Supplementary Material). This size is slightly larger than those obtained for AMLs of the same lipid containing nickel ferrite [25] or manganese ferrite [26] nanoparticles.…”

“…Compound 1 was incorporated into aqueous magnetoliposomes by the co-injection method, as already described [26]. In solid magnetoliposomes, compound 1 was incorporated by injection of an ethanolic solution together with the formation of the second lipid layer [26].…”

“…The SMLs were synthesized by the procedure previously developed by us using nickel ferrite and manganese ferrite nanoparticles [25,26]. SMLs containing iron oxide nanoparticles and with lipid bilayers of unsaturated lipids were previously obtained by…”

“…Magnetoliposomes containing magnetite nanoparticles have been used in MRI [21], environmental applications [22], thermo/chemotherapy [23] and treatment of other diseases [24]. These nanosystems take advantage of the very large saturation magnetization reported for magnetite nanoparticles [16,17,22], higher than the one observed for nickel ferrite [25] and manganese ferrite nanoparticles [26].…”