Post-transplant lymphoproliferative disease (PTLD) is an uncommon but life-threatening complication of solid-organ and blood stem-cell transplants. It responds poorly to therapy, including reduction of immunosuppression, interferon, antivirals or chemotherapy. Small series of PTLD successfully treated with rituximab have been reported, and experimental studies suggest that rapamycin inhibits growth of human Epstein-Barr virus-transformed B lymphocytes. We report two cases of PTLD after renal transplantation that were successfully treated with rituximab in association with rapamycin. This report suggests that rituximab associated with rapamycin could be an effective and safe treatment for PTLD.
Is there a specific pre-hospital treatment for COVID-19? Answer: There is no evidence to support the use of any pre-hospital treatment, both as a prophylactic (to reduce the incidence of new cases) or in suspected or confirmed cases (to reduce mortality) -recommendation number 7 of 10 recommendations. 1
The Brazilian Medical Association comprises various Specialty Societies, interacts with the Health System, public and private, municipal, state, and federal, and actively participates in the international scientific community through the World Medical Association and many other health institutions involved in education, assistance, or research. The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
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