Ultrasound irradiation was used for the first time towards the synthesis of new Nile Blue related benzo[a]phenoxazinium chlorides possessing isopentylamino, (2-cyclohexylethyl)amino and phenethylamino groups at 5-position of the heterocyclic system. The efficacy of sonochemistry was investigated with some of our earlier reported synthesis of benzo[a]phenoxazinium chlorides. This newer protocol proved competent in terms of reaction times and enhanced yields. Photophysical studies carried out in ethanol, water and simulated physiological conditions, revealed that emission maxima occurred in the range 644-656 nm, with high fluorescent quantum yields. Other attractive feature exhibited by these materials includes good thermal stability. These properties might be useful in the development of fluorescent probes for biotechnology.
Is there a specific pre-hospital treatment for COVID-19? Answer: There is no evidence to support the use of any pre-hospital treatment, both as a prophylactic (to reduce the incidence of new cases) or in suspected or confirmed cases (to reduce mortality) -recommendation number 7 of 10 recommendations. 1
The Brazilian Medical Association comprises various Specialty Societies, interacts with the Health System, public and private, municipal, state, and federal, and actively participates in the international scientific community through the World Medical Association and many other health institutions involved in education, assistance, or research. The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
Ultrasonic irradiation was demonstrated to be an efficient technique for activating various organic transformations, allowing short reaction times, high yields and sometimes good selectivity.Three new benzo[a]phenoxazinium chlorides possessing isopentylamino, (2-cyclohexylethyl)amino and phenethylamino groups at 5-position of the heterocyclic systems were efficiently synthesized under ultrasound irradiation. Photophysical characterization in ethanol and water, as well as acid-base equilibrium studies of the probes were carried out.
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