The authors' full names, academic degrees, and affiliations are listed in the Appendix. Prof. Orkin can be contacted at c . m .

Demographics and baseline HIV status Age (years) 40 49 29 40 31 Gender Transgender Male Male Male Transgender HIV-risk factor and exposure MSM, gym worker Bisexual man, health-care worker MSM, sexual worker participant in ChemSex session 6 days before MSM, dinner 5 days before with another person who was COVID-19 positive MSM, sexual worker

PEG-INF + RBV was significantly more effective than INF + RBV for the treatment of chronic hepatitis C in HIV co-infected patients, mainly of genotype 1 or 4.

A monkeypox (MPX) outbreak has expanded worldwide since May 2022. We tested 147 clinical samples collected at different time points from 12 patients by real-time PCR. MPX DNA was detected in saliva from all cases, sometimes with high viral loads. Other samples were frequently positive: rectal swab (11/12 cases), nasopharyngeal swab (10/12 cases), semen (7/9 cases), urine (9/12 cases) and faeces (8/12 cases). These results improve knowledge on virus shedding and the possible role of bodily fluids in disease transmission.

Objectives To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain. Methods A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time PCR assay in 127 Spanish centres until 17 March 2020. The follow-up censoring date was 17 April 2020. We collected demographic, clinical, laboratory, treatment and complications data. The primary endpoint was all-cause mortality. Univariable and multivariable Cox regression analyses were performed to identify factors associated with death. Results Of the 4035 patients, male subjects accounted for 2433 (61.0%) of 3987, the median age was 70 years and 2539 (73.8%) of 3439 had one or more comorbidity. The most common symptoms were a history of fever, cough, malaise and dyspnoea. During hospitalization, 1255 (31.5%) of 3979 patients developed acute respiratory distress syndrome, 736 (18.5%) of 3988 were admitted to intensive care units and 619 (15.5%) of 3992 underwent mechanical ventilation. Virus- or host-targeted medications included lopinavir/ritonavir (2820/4005, 70.4%), hydroxychloroquine (2618/3995, 65.5%), interferon beta (1153/3950, 29.2%), corticosteroids (1109/3965, 28.0%) and tocilizumab (373/3951, 9.4%). Overall, 1131 (28%) of 4035 patients died. Mortality increased with age (85.6% occurring in older than 65 years). Seventeen factors were independently associated with an increased hazard of death, the strongest among them including advanced age, liver cirrhosis, low age-adjusted oxygen saturation, higher concentrations of C-reactive protein and lower estimated glomerular filtration rate. Conclusions Our findings provide comprehensive information about characteristics and complications of severe COVID-19, and may help clinicians identify patients at a higher risk of death.

[1] Recent studies indicate that the rates of sea level rise (SLR) along the U.S. mid-Atlantic coast have accelerated in recent decades, possibly due to a slowdown of the Atlantic Meridional Overturning Circulation (AMOC) and its upper branch, the Gulf Stream (GS). We analyzed the GS elevation gradient obtained from altimeter data, the Florida Current transport obtained from cable measurements, the North Atlantic Oscillation (NAO) index, and coastal sea level obtained from 10 tide gauge stations in the Chesapeake Bay and the mid-Atlantic coast. An Empirical Mode Decomposition/Hilbert-Huang Transformation (EMD/HHT) method was used to separate long-term trends from oscillating modes. The coastal sea level variations were found to be strongly influenced by variations in the GS on timescales ranging from a few months to decades. It appears that the GS has shifted from a 6-8 year oscillation cycle to a continuous weakening trend since about 2004 and that this trend may be responsible for recent acceleration in local SLR. The correlation between long-term changes in the coastal sea level and changes in the GS strength was extremely high (R = À0.85 with more than 99.99% confidence that the correlation is not zero). The impact of the GS on SLR rates over the past decade seems to be larger in the southern portion of the mid-Atlantic Bight near Cape Hatteras and is reduced northward along the coast. The study suggests that regional coastal sea level rise projections due to climate change must take into account the impact of spatial changes in ocean dynamics.

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Hepatotoxicity but not clinical hepatitis was common in HIV-1-infected patients receiving nevirapine-containing regimens and the incidence steadily increased over time. Prolonged exposure to any antiretroviral therapy, coinfection with hepatitis C virus and abnormal baseline levels of alanine aminotransferase identified patients at a higher risk.