Zika virus is increasingly recognized as a fetal pathogen worldwide. We describe the first case of neonatal demise with travel-associated Zika virus infection in the United States of America, including a novel prenatal ultrasound finding. A young Latina presented to our health care system in Southeast Texas for prenatal care at 23 weeks of gestation. Fetal Dandy–Walker malformation, asymmetric cerebral ventriculomegaly, single umbilical artery, hypoechoic fetal knee, dorsal foot edema, and mild polyhydramnios were noted upon initial screening prenatal sonography at 26 weeks. A growth-restricted, microcephalic, and arthrogrypotic infant was delivered alive at 36 weeks but died within an hour despite resuscitation. The neonatal karyotype was normal. Flavivirus IgM antibodies were identified in the serum of the puerpera, once she disclosed that she had traveled from El Salvador to Texas in the early second trimester. Zika virus was identified in the umbilical cord and neonatal brain. Fetal arthritis may precede congenital arthrogryposis in cases of Zika virus infection and may be detectable by prenatal sonography. Physician and health care system vigilance is required to optimally address the significant and enduring Zika virus global health threat.
Objective
To estimate the SARS-CoV-2 antibody seroprevalence in HCWs at a secondary hospital in Mallorca, Spain.
Methods
All HCWs received an e-mail inviting them to take part in the study. Participants had a nasopharyngeal swab test performed for reverse transcription quantitative polymerase chain reaction (RT-qPCR) and serological tests to detect SARS-CoV-2 antibodies (primary study). Additionally, they were invited to complete a questionnaire on their exposure to COVID-19 individuals and their COVID-19-related symptoms (secondary study). Prevalence of antibodies (IgG, IgM or both) and 95% confidence intervals (CIs) were calculated.
Results
Seventy nine percent of the hospitalʼs HCWs (N = 2210) took part in the primary study. Antibodies were detected in 61 participants, a prevalence of 2.8% (95% CI: 2.5-3.1). The prevalence was slightly higher in nurses (3.4%), registrars (3.9%), and wardens (3.4%). Thirty nine percent of the primary study participants completed the secondary study questionnaire. Those with positive antibody test results had been in closer contact with COVID-19 individuals (60% vs 92%; p < 0.001).
Conclusion
After the first wave of the COVID-19 pandemic in Spain, the seroprevalence of SARS-CoV-2 antibodies in our secondary hospital HCWs was around 2.8%, which is slightly higher than the seroprevalence in the general population in our region. We believe it would be advisable to perform further seroprevalence studies during the second wave of the epidemic.
We report on familial occurrence of the Brachmann-de Lange syndrome (BDLS): a mildly affected father and his severely affected son and daughter who have different mothers. Both children are severely affected while the father has a much milder but definite BDLS phenotype. Our report documents the third example of male-to-male transmission and adds to the argument against exclusively maternal transmission in familial cases. In addition, our findings illustrate the occurrence of severe manifestations in cases of familial BDLS.
Despite growing interest in high-intensity interval training as a time-effective way for older adults to improve their health, there is little consensus regarding the better way to plan a HIIT intervention. Given the loss of function and health problems of an older adult population, the identification and characterization of interventions and strategies is a fundamental prerequisite. The goals of this review are examining high-intensity interval training as a way to improve health, and finding out the highestintensity viable HIIT protocol. Studies were included in this systematic review if: (1) they studied a population of older adults; (2) prescribed an intervention that can be described as high intensity; and (3) reported health-related outcome measures. The resulting 14 papers were included in our study. The present review found that high-intensity interval training is an effective tool to improve indicators of body composition as well as cardiometabolic and cardiovascular health, with 90-95% HRmax cycle ergometer sessions held two-three times a week, with a minimum session length of 40 minutes, in an intervention at least 12-week long, effecting significant improvements on the health of participants. Recommendations regarding optimal exercise duration and rest intervals must remain ambiguous given the scarcity of published literature and the methodology and limitations of those studies that are already available
We report on familial occurrence of the Brachmann-de Lange syndrome (BDLS): a mildly affected father and his severely affected son and daughter who have different mothers. Both children are severely affected while the father has a much milder but definite BDLS phenotype. Our report documents the third example of male-to-male transmission and adds to the argument against exclusively maternal transmission in familial cases. In addition, our findings illustrate the occurrence of severe manifestations in cases of familial BDLS.
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