Of 2434 individuals who received Thorotrast in Portugal, mostly from 1930 to 1950, 1237 (or 51%) have been traced and followed up. As of 31 March 1974,931 of these had died: 16 from local Thorotrast granulomas, 25 from liver cirrhosis or fibrosis. 121 from malignant solid tumors (including 6 on the edge of large Thorotrast deposits, 75 tumours of the liver and other reticuloendothelial tissues, 5 bronchial carcinomas, 4 bone turnours, and 31 other solid tumours), 23 from fatal blood dyscrasias (including 12 leukemias, 8 aplastic anemias, and 3 other fatal blood diseases). These causes of death are significantly above the corresponding expected number in the general Portuguese population, and in a control group of 829 traced individuals injected with a non-radioactive contrast drug and followed up concomitantly.
1. A case of essential osteolysis, progressing for thirteen years and involving the right femur and pelvis of a boy who was thirteen years old at the time of onset, is presented. 2. The histological appearance of fragments of bone and soft tissue removed from the affected thigh is described. 3. No evidence that might throw light on the etiology of the disease was obtained from biochemical investigations or from the histological studies. 4. None of the many lines of treatment that were tried had any effect upon the progress of the disease.
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