“…In comparison with Portuguese, Indiana-Maryland, and Iowa families showing nervous system involvement (Andrade, 1952;Rukavina et al, 1956;Silva Horta et al, 1964;Andrade et al, 1969;Mahloudji et al, 1969;Van Allen et al, 1969), the unique neuropathological feature of the present case is the heavy leptomeningeal amyloid deposition together with the blood vessels, in contrast with the slight peripheral nerve involvement in the extremities. Moreover, such extensive cerebral infarcts secondary to the characteristic arterial alterations can not be found out in the previous reports of this disease.…”